Table 3.
Associations of VDR SNP genotypes and metabolic and anthropometric measures in response to vitamin D3 supplementation (4000 IU/day) in breast cancer survivors using multivariate multiple regression
| Changes in varibles | APa1, β (95% CI) | TaqI, β (95% CI) | BsmI, β (95% CI) | FokI, β (95% CI) | Cdx2, β (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Aa (n = 52) |
aa (n = 18) |
Tt (n = 67) |
tt (n = 14) |
Bb (n = 65) |
bb (n = 16) |
Ff (n = 66) |
ff (n = 17) |
GA (n = 52) |
AA (n = 14) |
|
|
BMI, Kg/m2 P value |
0.13 (−0.17,0,44) 0.39 |
0.21 (− 0.23, 0.66) 0.35 |
− 0.06 (− 0.37,.24) 0.66 |
0.03 (− 0.45,0.53) 0.87 |
0.08 (− 0.21,0.38) 0.58 |
0.06 (− 0.41,0.54) 0.78 |
0.01 (− 0.27,0.31) 0.90 |
− 0.2 (− 0.6,0.2) 0.37 |
−0.16 (− 0.46. 0.14) 0.29 |
0 (− 0.48,0.50) 0.96 |
|
WC, cm P value |
−0.4 (−3.3, 2.3) 0.72 |
0.8 (−3.2,4.8) 0.69 |
−1.4 (−4.1,1.3) 0.31 |
− 1.3 (−5.7,3.1) 0.55 |
2.7 (0.1,5.3) 0.04 |
3.9 (− 0.2,8.1) 0.06 |
1.2 (− 1.3,3.9) 0.34 |
−0.8 (− 4.9,3.2) 0.68 |
1.8 (− 0.8,4.6) 0.17 |
−1.2 (− 5.6, 3.2) 0.59 |
|
HC, cm P value |
0.9 (− 1.1,3.0) 0.37 |
0.9 (−2.0,4.0) 0.53 |
1.9 (− 0.1,3.9) 0.06 |
0.6 (− 2.6,3.9) 0.70 |
0.9 (− 1.0,2.9) 0.32 |
0.1 (− 3.0, 3.3) 0.93 |
1.4 (− 0.5,3.3) 0.15 |
0.1 (− 2.9, 3.1) 0.93 |
−0.8 (− 2.9,1.1) 0.41 |
0.17 (− 3.1,3.5) 0.91 |
|
Fat mass (%) P value |
0.08 (− 0.70,0.86) 0.83 |
0.53 (− 0.59,1.66) 0.34 |
−0.1 (− 0.9,0.6) 0.70 |
−0.2 (− 1.5,0.9) 0.66 |
0.2 (− 0.5, 1.0) 0.53 |
0.5 (− 0.6,1.8) 0.3 |
0.4 (− 0.3,1.1) 0.28 |
−0.8 (− 2.0,0.3) 0.14 |
0.06 (− 0.74,0.87) 0.86 |
−0.2 (− 1.5, 1.1) 0.75 |
|
Muscle mass (%) P value |
0.2 (−41.9,42.3) 0.99 |
71.3 (10.7131.9) 0.02 |
− 22.0 (− 63.9,19.8) 0.30 |
− 25.7 (− 93.3,41.8) 0.45 |
− 22.4 (− 62.1,17.3) 0.26 |
− 26.7 (− 90.6,37.2) 0.41 |
19.7 (− 19.9,59.4) 0.32 |
1.7 (− 59.7,63.2) 0.95 |
20.3 (− 20.6,61.3) 0.32 |
− 6.8 (− 73.8,60.1) 0.84 |
|
Trunk fat (%) P value |
0. 2 (− 0.8,1.3) 0.67 |
0.5 (− 1.0,2.1) 0.65 |
− 0.06 (− 1.15, 1.02) 0.90 |
−0.1 (− 1.9, 1.5) 0.84 |
0.3 (− 0.7,1.4) 0.58 |
0.7 (− 0.9,2.5) 0.38 |
0.5 (− 0.5,1.6) 0.34 |
− 1.0 (− 2.7,0.6) 0.22 |
0.2 (− 0.9,1.3) 0.71 |
− 0.2 (− 2.1,1.5) 0.77 |
|
Visceral fat P value |
0.1 (− 0.2,0.4) 0.5 |
0.2 (− 0.2,0.7) 0.37 |
− 0.1 (− 0.4,0.2) |
−0.1 (− 0.7,0.3) |
− 0.04 (− 0.37,0.27) 0.77 |
0.3 (− 0.1,0 .8) 0.17 |
0.1 (− 0.1,0.4) 0.32 |
−0.2 (− 0.7,0.2) 0.38 |
−0.03 (− 0.3,0.3) 0.82 |
−0.04 (− 0.6,0.5) 0.86 |
|
LDL, mg/dL P value |
− 4.0 (− 15.0,6.8) 0.46 |
− 17.9 (− 33.6, − 2.3) 0.02 |
0.6 (− 10.1,11.3) 0.90 |
7.4 (− 10.0,24.9) 0.40 |
3.9 (− 6.3,14.2) 0.44 |
2.1 (− 14.5,18.8) 0.79 |
3.2 (− 7.0,13.5) 0.53 |
−2.5 (− 18.5,13.5) 0.75 |
−6.5 (− 16.9,3.8) 0.21 |
− 18.1 (− 35.3, − 0.9) 0.03 |
|
HDL, mg/dL P value |
0.9 (− 3.5,5.4) 0.68 |
2.3 (− 4.0,8.8) 0.46 |
−2.2 (− 6.5,2.06) 0.30 |
0.84 (− 6.1,7.8) 0.81 |
− 1.8 (− 5.9,2.3) 0.38 |
3.3 (− 3.2,10.0) 0.31 |
1.4 (−2.6.5.5) 0.48 |
− 0.6 (− 7.10,5.7) 0.83 |
− 0.7 (− 5.0, 3.4) 0.72 |
1.2 (− 5.7, 8.2) 0.72 |
|
TC, mg/dL P value |
−4.1 (− 18.9,10.7) 0.58 |
−4.8 (− 26.0,16.3) 0.65 |
−9.7 (− 23.9,4.4) 0.17 |
3.7 (− 19.3,26.7) 0.75 |
3.8 (− 10.1,17.9) 0.58 |
11.4 (− 11.3,34.2) 0.32 |
−1.2 (− 15.3,12.7) 0.85 |
−3.8 (− 25.7,18.0) 0.72 |
−9.8 (− 24.1, 4.4) 0.17 |
−22.1 (− 45.7, 1.3) 0.06 |
|
TG, mg/dL P value |
6.3 (− 14.1,26.8) 0.54 |
− 13.1 (− 42.4,16.2) 0.37 |
2.5 (− 17.3,22.4) 0.79 |
21.2 (− 11.0,53.6) 0.19 |
8.6 (− 10.4, 27.7) 0.37 |
−4.5 (− 35.4, 26.3) 0.77 |
−9.4 (− 28.4,9.5) 0.32 |
6.2 (− 23.3,35.8) 0.67 |
− 3.0 (− 22.6,16.4) 0.75 |
−25.9 (− 58.1, 6.2) 0.11 |
BMI Body mass index, WC Waist circumference, HC Hip circumference, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, TG Triglycerides
All values were adjusted for age, baseline 25-hydroxy vitamin D (25(OH)D), energy intake, fat intake and physical activity