Table 5.
Total, direct, and indirect effects of VDR SNPs on LDL-C, WC and muscle mass percentage for plasma 25-hydroxy vitamin D (25(OH)D changes as the mediator
| Outcomes | Exposures | ACME (95% CI)a | ADE (95% CI)b | Total effect (95% CI) |
Proportion mediated 95% CI | ||||
|---|---|---|---|---|---|---|---|---|---|
| LDL-C (mg/dL) | ApaI | aa | Aa | aa | Aa | aa | Aa | aa | Aa |
| −0.07 (−3.58, 3.45) | 0.01 (−0.99, 1.26) | −17.92 (−34.00, −2.29) | −4.17 (−15.00, 6.35) | − 17.99 (− 34.12, −2.21) | −4.15 (− 15.10, 6.52) | 0.004 (− 0.33, 0.32) | 0.008 (− 0.65, 0.77) | ||
| Cdx2 | GG | GA | GG | GA | GG | GA | GG | GA | |
| −0.15 (−3.22, 2.94) | − 0.01 (−1.06, 0.87) | −17.41 (− 32.73, − 0.60) | −6.12 (− 16.10, 3.56) | −17.57 (− 32.93, − 0.73) | −6.14 (− 16.23, 3.57) | 0.007 (−0.25, 0.31) | 0.001 (− 0.50, 0.35) | ||
| WC (cm) | BsmI | bb | Bb | bb | Bb | bb | Bb | bb | Bb |
| 0.01 (−0.02, 0.06) | −0.002 (− 0.02, 0.02) | 0.16 (− 0.09, 0.44) | 0.08 (− 0.08, 0.25) | 0.17 (− 0.08, 0.46) | 0.07 (− 0.09, 0.26) | 0.02 (− 0.90, 0.91) | −0.003 (− 0.94, 0.85) | ||
| Muscle mass (%) | ApaI | aa | Aa | aa | Aa | aa | Aa | aa | Aa |
| −0.43 (−3.28, 1.66) | −0.38 (−2.21, 0.80) | −8.40 (− 23.36, 7.26) | −12.73 (− 21.86, − 3.31) | −8.83 (− 23.96, 6.75) | −13.12 (− 22.49, − 3.44) | 0.01 (− 1.15, 0.93) | 0.01 (−0.09, 0.19) | ||
aaverage causal mediation effects, baverage direct effects
Adjusted for age, baseline Body Mass Index (BMI), energy intake, fat intake and physical activity
LDL-C Low-density lipoprotein cholesterol, WC Waist circumference
AA, GG and BB were considered as reference category for ApaI, Cdx2 and BsmI respectively