Table 1.
Characteristics of patients in the primary and validation cohorts
| Characteristic | Primary cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|
| CAP | Pulmonary TB | p value | CAP | Pulmonary TB | p-value | |
| Gender, No. (%) | 0.151 | 0.047* | ||||
| Male | 25 (54.35) | 26 (65.00) | 8 (50.00) | 11 (84.62) | ||
| Female | 21 (45.65) | 14 (35.00) | 8 (50.00) | 2 (15.38) | ||
| Age, mean ± SD, years | 4.51 ± 3.44 | 3.41 ± 3.66 | 0.181 | 2.69 ± 3.10 | 1.77 ± 1.62 | 0.332 |
| Hemoptysis, No. (%) | 0.083 | – | ||||
| + | 0 (0.0) | 3 (7.50) | 0 (0.00) | 0 (0.00) | ||
| - | 46 (100.0) | 37 (92.50) | 16 (100.00) | 13 (100.00) | ||
| Cough, No. (%) | 0.324 | 0.82 | ||||
| - | 2 (4.35) | 4 (10.00) | 0 (0.00) | 3 (23.08) | ||
| + | 44 (95.65) | 36 (90.00) | 16 (100.00) | 10 (76.92) | ||
| fever, No. (%) | 0.143 | – | ||||
| - | 1 (2.17) | 4 (10.00) | 9 (56.25) | 5 (38.46) | ||
| + | 45 (97.83) | 36 (90.00) | 7 (43.75) | 8 (61.54) | ||
| Expectoration, No. (%) | 0.129 | 0.358 | ||||
| - | 20 (43.48) | 24 (60.00) | 6 (37.50) | 6 (46.15) | ||
| + | 26 (56.52) | 16 (40.00) | 10 (62.50) | 7 (53.85) | ||
| duration of fever (days) | <0.001*** | <0.001 | ||||
| <10 | 43 (93.48) | 15 (37.50) | 15 (93.75) | 3 (23.08) | ||
| ≥10 | 3 (6.52) | 25 (62.50) | 1 (6.25) | 10 (76.92) | ||
| WBC (*10^9/L), No. (%) | 0.247 | 0.264 | ||||
| Median(IQR) | 8.42 (6.70-10.16) | 8.40 (7.10-11.41) | 14.98 (14.18-17.26) | 16.89 (16.30-19.77) | ||
| Normal | 27 (58.70) | 20 (50.00) | 5 (31.25) | 5 (38.46) | ||
| Abnormal | 19 (41.30) | 20 (50.00) | 11 (68.75) | 8 (61.54) | ||
| CRP (mg/L), No. (%) | 0.365 | 0.381 | ||||
| Median (IQR) | 23.30 (11.53-56.25) | 15.70 (9.44-33.88) | 28.25 (16.00-71.75) | 29.00 (14.00-53.60) | ||
| Normal | 7 (15.22) | 8 (20.00) | 1 (6.25) | 3 (23.08) | ||
| Abnormal | 39 (84.78) | 32 (80.00) | 15 (93.75) | 10 (76.92) | ||
| Radiomic signature1 median | 0.53 (0.32 to 0.86) | <0.001*** | 0.53 (0.33 to 0.74) | 0.018* | ||
| Radiomic signature2 median | 0.54 (0.12 to 0.98) | <0.001*** | 0.54 (0.20 to 1.26) | <0.001*** | ||
NOTE. The p-value was derived from univariable association analyses of each characteristic and of the two diseases. * denotes p-value< 0.05; ** denotes p-value< 0.01; *** denotes p-value<0.001
Abbreviations: WBC white blood cell, CRP C-reaction protein