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Scoring of cutaneous adverse events
| Reaction | Scale |
|---|---|
| No reaction | – |
| Erythema only (doubtful reaction) | +? |
| Erythema with infiltration and papules | + |
| Erythema with edema, papules, and vesicles | ++ |
| Formation of bulla(e) | +++ |
| Irritant reactiona | IR |
aIrritant reactions (IR) tend to form a sharply demarcated area, in contrast to a spreading response in allergic reactions, and tend to disappear within several days once the irritating substance is removed
