Fuel flex analysis of syncytiotrophoblast of lean women, women with obesity, and women with A2GDM with either a male or female fetus. (A and B) Dependency, capacity, and flexibility for glucose, glutamine, and fatty acids with (A) both sexes combined (n = 13 lean, 10 obese, and 9 A2GDM) or (B) in male and female trophoblast of lean women, women with obesity, and women with A2GDM (n = 6, 5, and 4 males for lean, obese, and GDM, respectively, and n =7, 5, and 5 females for lean, obese, and GDM, respectively). Median, minimum, and maximum values and interquartile range are shown. *P < 0.05, **P < 0.01, *** P < 0.001, as measured by a Kruskal–Wallis test with a Dunn post hoc test.