Table 3.

GUIDANCE FOR MONITORING PATIENTS FOR SIGNS OF HUS AND CLS

	HUS	CLS
Parameters to check	• Hemoglobin  • Platelet count  • Serum creatinine	• Weight  • Blood pressure
Signs and symptoms	See Table 2	See Table 2
Consider a diagnosis if the following are present	≥ Grade 2 creatinine increase AND one of the following:  • hemoglobin decreased by 1 g/dL  • platelet count < 25 000/mm3 (unrelated to underlying disease)	If weight has increased by ≥ 10% from day 1 of each cycle, and the patient is hypotensive, check for peripheral edema, hypoalbuminemia, and respiratory symptoms, including dyspnea and cough
If suspected, check the following	Evidence of hemolysis:  • blood LDH  • indirect bilirubin  • blood smear schistocytes	• Decrease in oxygen saturation  • Evidence of pulmonary edema And/or  • Serosal effusions
Suggested treatment	Appropriate supportive measures, including fluid repletion and hemodynamic monitoring; hospitalization should be considered if clinically indicated	Standard symptomatic treatment, including administration of concomitant corticosteroids (PO/IV); hospitalization as clinically indicated
Time to onset	May occur during any cycle of treatment	May occur during any cycle of treatment; usually before day 8

CLS, capillary leak syndrome; HUS, hemolytic uremic syndrome; IV, intravenous; LDH, lactate dehydrogenase; PO, per oral