. Author manuscript; available in PMC: 2020 Jun 1.

Published in final edited form as: Semin Oncol Nurs. 2019 May 10;35(3):291–299. doi: 10.1016/j.soncn.2019.04.011

Table 2.

Genetic polymorphisms associated with post-cancer treatment pain.

Gene	SNP rsID	Nucleotide Change		Pathway/Function	Associated Pain Phenotype			Type of Cancer		Study
IL1R2	rs11674595	T>C		Inflammation	Persistent postsurgical pain			Breast cancer		Stephens et al, 2014³²
IL-10 Haplotype A8	rs3024505 rs3024498 rs3024496 rs1878672 rs1518111 rs1518110 rs3024491	Minor “C” Minor “G” Minor “C” Minor “G” Minor “A” Minor “T” Minor “T”		Inflammation	Persistent postsurgical pain			Breast cancer		Stephens et al, 2014³²
IL-6	rs20069840	C>G		Inflammation	Persistent postsurgical pain			Breast cancer		Stephens et al, 201 7³³
CXCL8	rs4073	T>A		Inflammation	Persistent postsurgical pain			Breast cancer		Stephens et al, 2017³³
TNF	rs1800610	C>A		Inflammation	Persistent postsurgical pain			Breast cancer		Stephens et al, 2017³³
COMT	rs4680	G>A (Val158Met)		Neurotransmission			Postmastectomy pain, pressure pain hypersensitiVity	Breast cancer		Fernández-des-las- Peñas et al, 2012³⁴
COMT	rs165774 rs887200	G>A T>C		Neurotransmission			Experimental and acute postoperatiVe pain	Breast cancer		Kambur et al, 2013³⁵
COMT	rs4680 rs4818			Neurotransmission			Pain interference and severity	Breast cancer		Young et al, 20 17⁴³
CACNG2 A-C-C haplotype	rs4820242 rs2284015 rs2284017	A>G C>G C>T		Neurotransmission (calcium channel)			Chronic postmastectomy pain	Breast cancer		Bortsov et al, 2018³⁶
KCNA1	rs4766311	C>T		Neurotransmission (potassium channel)			Persistent breast postsurgical pain	Breast cancer		Langford et al, 2015³⁷
KCND2	rs1072198	A>G		Neurotransmission (potassium channel)			Persistent breast postsurgical pain	Breast cancer		Langford et al, 2015³⁷
KCNJ3	rs12995382 rs17641121	T>C T>C		Neurotransmission (potassium channel)			Persistent breast postsurgical pain	Breast cancer		Langford et al, 2015³⁷
KCNJ6	rs858003	C>T		Neurotransmission (potassium channel)			Persistent breast postsurgical pain	Breast cancer		Langford et al, 2015³⁷
KCNK9	rs2542424 rs2545457	A>G T>C		Neurotransmission T>C (potassium channel)			Persistent breast postsurgical pain	Breast cancer		Langford et al, 2015³⁷
CYP17A1	rs4919686 rs4919683 rs4919687 rs3781287 rs10786712 rs6163 rs743572			Drug transport and metabolism			Arthralgia	Patients with breast cancer treated with Als		Garcia-Giralt et al, 2013⁴¹
CYP19A1	rs4775936			Drug transport and metabolism			Arthralgia (worsening pain)	Patients with breast cancer treated with Als		Garcia-Giralt et al, 2013⁴¹
CYP27B1	rs4646536			Drug transport and metabolism			Arthralgia	Patients with breast cancer treated with Als		Garcia-Giralt et al, 2013⁴¹
VDR	rs11568820			Drug transport and metabolism			Arthralgia	Patients with breast cancer treated with Als		Garcia-Giralt et al, 2013⁴¹
OPG	rs2073618		G>C	lnflammation (cytokine receptor)			Musculoskeletal pain severity	Patients with breast cancer treated with Als	Lintermans et al, 2016⁴²
P2RY12	rs3732765 rs9859538 rs17283010 rs11713504 rs10935840		C>T C>T C>T A>G A>G	Neurotransmission (purinergic signaling, activating microglia)			Pain severity, 24-hour postoperative pain (rs3732765)	Cancer pain patients patients	Sumitani et al, 2018⁴⁶
AQP7	rs76608797 rs33386144		C>A G>A	Other (water-selective membrane channel)			Pain	Bone metastases (patients undergoing palliative radiation therapy)	Furfari et al, 20 17⁴⁴
PLAUR	rs4760		A>G (Leu193Pro)	Other (regulation of cell surface protein and extracellular matrix)			Pain	Bone metastases (patients undergoing palliative radiation therapy)	Furfari et al, 20 17⁴⁴
ELAC2	rs11545302		T>C	Other (tRNA processing and TGF-β signaling)			Pain	Bone metastases (patients undergoing palliative radiation therapy)		Furfari et al, 20 17⁴⁴
TNF-α	rs1800629		−308G>A	Inflammation		Incidence of neck pain, throat pain		Differentiated thyroid cancer (patients receiving ¹³¹I radiotherapy)		Liu et al, 2018⁴⁵
ATM	rs11212570			Other (DNA-damage response)		Throat pain		Differentiated thyroid cancer (patients receiving ¹³¹I radiotherapy)		Liu et al, 2018⁴⁵
TNF-β	rs1800469 rs2241716			Inflammation		Throat pain		Differentiated thyroid cancer (patients receiving ¹³¹I radiotherapy)		Liu et al, 2018⁴⁵
NF-κB	rs230493			Inflammation		Throat pain		Differentiated thyroid cancer (patients receiving ¹³¹I radiotherapy)		Liu et al, 2018⁴⁵

Abbreviations: AI, aromatase inhibitor; ATM, ataxia-telangiectasia mutated gene; AQP7, aquaporin 7; CACNG2, calcium channel voltage-dependent gamma subunit 2; COMT, catechol-O-methyltransferase; CXCL8, C-X-C motif chemokine ligand 8; CYP17A1, cytochrome P450 family 17 subfamily A member 1; CYP19A1, cytochrome P450 family 19 subfamily A member 1; CYP27B1, cytochrome P450 family 27 subfamily B member 1; ELAC2, ElaC Ribonuclease Z 2; IL-6, interleukin 6; IL-10, interleukin 10; IL1R2, interleukin 1 receptor type 2; KCNA1, potassium voltage-gated channel subfamily A member 1; KCND2, potassium voltage-gated channel subfamily D member 2; KCNJ3, potassium voltage-gated channel subfamily J member 3; KCNJ6, potassium voltage-gated channel subfamily J member 6; KCNK9, potassium voltage-gated channel subfamily K member 9; Leu193Pro: a substitution of leucine (Leu) for proline (Pro) at codon 193; NF-κB, nuclear factor kappa B; OPG, osteoprotegerin; PLAUR, plasminogen activator urokinase receptor; P2RY12, purinergic receptor P2Y12; SNP, single nucleotide polymorphism; TGF-β, transforming growth factor beta; TNF, tumor necrosis factor; TNF-α, tumor necrosis factor alpha; TNF-β, tumor necrosis factor beta; tRNA, transfer ribonucleic acid; Val158Met, a substitution of valine (Val) for methionine (Met) at codon 158; VDR, vitamin D receptor.