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. Author manuscript; available in PMC: 2019 Aug 9.
Published in final edited form as: Cancer Biol Ther. 2008 Aug 30;7(8):1212–1225. doi: 10.4161/cbt.7.8.6220

Figure 7.

Figure 7.

RB-phosphorylation is inhibited by a Cav-1 mimetic peptide in CAFs. Treatment of CAFs with a Cav-1 mimetic peptide inhibited the phosphorylation of RB as shown by immunufluorescence (Upper), using a phospho-specific antibody that recognizes endogeneous RB only when phosphorylated at serine 807/811. PCNA levels were also decreased by the Cav-1 peptide (Middle). Penetratin (Pen) alone did not affect the levels of phospho-RB or PCNA. DAPI staining shows the nuclei of the cells imaged (Lower). Images were taken at 20x. Virtually identical results were obtained with 5, 10 and 20 μM dosages of the Cav-1 mimetic peptide.