Table 1.
Breast cancer-associated fibroblast (CAF) gene signature—upregulated transcripts
| ADAM12 | ADAM metallopeptidase domain 12 (meltrin alpha) |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
| ANLN | anillin, actin binding protein (scraps homolog, Drosophila) |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
| ARSI | arylsulfatase family, member I |
| AURKA | aurora kinase A |
| BHLHB2 | basic helix-loop-helix domain containing, class B, 2 |
| BIRC5 | baculoviral IAP repeat-containing 5 (survivin) |
| BLM | Bloom syndrome |
| BRCA1 | breast cancer 1, early onset |
| BUB1 | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) |
| BUB1B | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) |
| C13orf3 | chromosome 13 open reading frame 3 |
| C14orf145 | chromosome 14 open reading frame 145 |
| C20orf42 | chromosome 20 open reading frame 42 |
| C5orf13 | chromosome 5 open reading frame 13 |
| C9orf140 | chromosome 9 open reading frame 140 |
| C9orf46 | chromosome 9 open reading frame 46 |
| CALB2 | calbindin 2, 29 kDa (calretinin) |
| CASC5 | cancer susceptibility candidate 5 |
| CBR3 | carbonyl reductase 3 |
| CCDC34 | coiled-coil domain containing 34 |
| CCNB2 | cyclin B2 |
| CCNF | cyclin F |
| CD44 | CD44 molecule (Indian blood group) |
| CDC2 | cell division cycle 2, G1 to S and G2 to M |
| CDC20 | CDC20 cell division cycle 20 homolog (S. cerevisiae) |
| CDC45L | CDC45 cell division cycle 45-like (S. cerevisiae) |
| CDCA1 | cell division cycle associated 1 |
| CDCA3 | cell division cycle associated 3 |
| CDCA5 | cell division cycle associated 5 |
| CDCA8 | cell division cycle associated 8 |
| CENPA | centromere protein A |
| CENPF | centromere protein F, 350/100ka (mitosin) |
| CENPK | centromere protein K |
| CENPM | centromere protein M |
| CEP55 | centrosomal protein 55 kDa |
| CKAP2L | cytoskeleton associated protein 2-like |
| COTL1 | coactosin-like 1 (Dictyostelium) |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 |
| DEPDC1 | DEP domain containing 1 |
| DKFZP761M1511 | NA |
| DKFZp762E1312 | NA |
| DLG7 | discs, large homolog 7 (Drosophila) |
| DTL | denticleless homolog (Drosophila) |
| E2F7 | E2F transcription factor 7 |
| E2F8 | E2F transcription factor 8 |
| EPHA4 | EPH receptor A4 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAM83D | family with sequence similarity 83, member D |
| FANCD2 | Fanconi anemia, complementation group D2 |
| FKBP5 | FK506 binding protein 5 |
| FOXM1 | forkhead box M1 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GTSE1 | G-2 and S-phase expressed 1 |
| HCAP-G | non-SMC condensin I complex, subunit G |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) |
| IL27RA | interleukin 27 receptor, alpha |
| KCNMA1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| KIAA0101 | KIAA0101 |
| KIAA1794 | KIAA1794 |
| KIF11 | kinesin family member 11 |
| KIF14 | kinesin family member 14 |
| KIF15 | kinesin family member 15 |
| KIF20A | kinesin family member 20A |
| KIF23 | kinesin family member 23 |
| KIF2C | kinesin family member 2C |
| KIF4A | kinesin family member 4A |
| KNTC2 | kinetochore associated 2 |
| LOC146909 | NA |
| LOC150084 | NA |
| LOC283824 | NA |
| LOC653594 | NA |
| LPXN | leupaxin |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MCM10 | MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) |
| MCM2 | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) |
| MCM5 | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) |
| MELK | maternal embryonic leucine zipper kinase |
| MET | met proto-oncogene (hepatocyte growth factor receptor) |
| MKI67 | antigen identified by monoclonal antibody Ki-67 |
| MLF1IP | MLF1 interacting protein |
| MMP1 | matrix metallopeptidase 1 (interstitial collagenase) |
| MND1 | meiotic nuclear divisions 1 homolog (S. cerevisiae) |
| MT1M | metallothionein 1 M |
| NEBL | nebulette |
| NEFL | neurofilament, light polypeptide 68 kDa |
| NEK2 | NIMA (never in mitosis gene a)-related kinase 2 |
| NET1 | neuroepithelial cell transforming gene 1 |
| NPHP1 | nephronophthisis 1 (juvenile) |
| NRG1 | neuregulin 1 |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| ODZ2 | odz, odd Oz/ten-m homolog 2 (Drosophila) |
| OIP5 | Opa interacting protein 5 |
| PBK | PDZ binding kinase |
| PLAUR | plasminogen activator, urokinase receptor |
| PLK1 | polo-like kinase 1 (Drosophila) |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) |
| POLE2 | polymerase (DNA directed), epsilon 2 (p59 subunit) |
| PPAPDC1A | phosphatidic acid phosphatase type 2 domain containing 1A |
| PRC1 | protein regulator of cytokinesis 1 |
| PRIM1 | primase, polypeptide 1, 49 kDa |
| PTHLH | parathyroid hormone-like hormone |
| PTTG1 | pituitary tumor-transforming 1 |
| RACGAP1 | Rac GTPase activating protein 1 |
| RAD51AP1 | RAD51 associated protein 1 |
| RAD54L | RAD54-like (S. cerevisiae) |
| RNASEH2A | ribonuclease H2, subunit A |
| RRM2 | ribonucleotide reductase M2 polypeptide |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SLC16A3 | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) |
| SMS | spermine synthase |
| SPAG5 | sperm associated antigen 5 |
| SPBC24 | spindle pole body component 24 homolog (S. cerevisiae) |
| SPBC25 | spindle pole body component 25 homolog (S. cerevisiae) |
| STMN1 | stathmin 1/oncoprotein 18 |
| STMN3 | stathmin-like 3 |
| TCF19 | transcription factor 19 (SC1) |
| TK1 | thymidine kinase 1, soluble |
| TOP2A | topoisomerase (DNA) II alpha 170 kDa |
| TPX2 | TPX2, microtubule-associated, homolog (Xenopus laevis) |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TSPAN13 | tetraspanin 13 |
| TTK | TTK protein kinase |
| TYMS | thymidylate synthetase |
| XYLT1 | xylosyltransferase I |
Genes shown in BOLD are part of an RB/E2F gene signature. Table represents 118 known genes and 8 known transcripts.