Table 2.
Breast cancer-associated fibroblast (CAF) gene signature—downregulated transcripts
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) |
| ADD3 | adducin 3 (gamma) |
| ADH1B | alcohol dehydrogenase IB (class I), beta polypeptide |
| AKR1C3 | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type III) |
| ALS2CR19 | amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 1 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 |
| BEX1 | brain expressed, X-linked 1 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
| CD36 | CD36 molecule (thrombospondin receptor) |
| COL16A1 | collagen, type XVI, alpha 1 |
| COP1 | constitutive photomorphogenic protein |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide |
| DBC1 | deleted in bladder cancer 1 |
| DSCR1L1 | Down syndrome critical region gene 1-like 1 |
| EEA1 | early endosome antigen 1, 162 kD |
| EMX2 | empty spiracles homolog 2 (Drosophila) |
| EMX2OS | empty spiracles homolog 2 (Drosophila) opposite strand |
| FABP3 | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) |
| FHL1 | four and a half LIM domains 1 |
| GALNTL1 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide, N-acetylgalactosaminyltransferase-like 1 |
| HNMT | histamine N-methyltransferase |
| INMT | indolethylamine N-methyltransferase |
| ITGA1 | integrin, alpha 1 |
| ITPR1 | inositol 1,4,5-triphosphate receptor, type 1 |
| KCTD12 | potassium channel tetramerisation domain containing 12 |
| LEPR | leptin receptor |
| LMCD1 | LIM and cysteine-rich domains 1 |
| LOC221091 | NA |
| LOC387763 | NA |
| LRRC32 | leucine rich repeat containing 32 |
| MACF1 | microtubule-actin crosslinking factor 1 |
| MALAT1 | metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 |
| MID1 | midline 1 (Opitz/BBB syndrome) |
| MRVI1 | murine retrovirus integration site 1 homolog |
| MTBP | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104 kDa |
| MYH10 | myosin, heavy polypeptide 10, non-muscle |
| NANOS1 | nanos homolog 1 (Drosophila) |
| NID2 | nidogen 2 (osteonidogen) |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 |
| PDGFD | platelet derived growth factor D |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide |
| PELO | pelota homolog (Drosophila) |
| PKIB | protein kinase (cAMP-dependent, catalytic) inhibitor beta |
| PLGLA1 | plasminogen-like A1 |
| PLXND1 | plexin D1 |
| PPARG | peroxisome proliferative activated receptor, gamma |
| PPL | periplakin |
| PRKG1 | protein kinase, cGMP-dependent, type I |
| RBMS3 | RNA binding motif, single stranded interacting protein |
| RSPO3 | R-spondin 3 homolog (Xenopus laevis) |
| SLC40A1 | solute carrier family 40 (iron-regulated transporter), member 1 |
| SLC5A3 | solute carrier family 5 (inositol transporters), member 3 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59 kDa, basic component 1) |
| STAT1 | signal transducer and activator of transcription 1, 91 kDa |
| STMN2 | stathmin-like 2 |
| STAU2 | staufen, RNA binding protein, homolog 2 (Drosophila) |
| SUSD2 | sushi domain containing 2 |
| SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 |
| SYNPO2 | synaptopodin 2 |
| THRB | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) |
| TMEM16D | transmembrane protein 16D |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 |
| TNXB | tenascin XB |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) |
| ZCCHC7 | zinc finger, CCHC domain containing 7 |
| ZFP36L2 | zinc finger protein 36, C3H type-like 2 |
Table represents 66 known genes and 2 known transcripts.