Table 4.
Breast cancer-associated fibroblast (CAF) RB/E2F gene signature—44 upregulated genes
| ANLN | anillin, actin binding protein (scraps homolog, Drosophila) |
| AURKA | aurora kinase A |
| BIRC5 | baculoviral IAP repeat-containing 5 (survivin) |
| BLM | Bloom syndrome |
| BRCA1 | breast cancer 1, early onset |
| BUB1 | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) |
| CCNB2 | cyclin B2 |
| CCNF | cyclin F |
| CDC2 | cell division cycle 2, G1 to S and G2 to M |
| CDC20 | CDC20 cell division cycle 20 homolog (S. cerevisiae) |
| CDC45L | CDC45 cell division cycle 45-like (S. cerevisiae) |
| CDCA3 | cell division cycle associated 3 |
| CDCA5 | cell division cycle associated 5 |
| CDCA8 | cell division cycle associated 8 |
| CENPA | centromere protein A |
| FANCD2 | Fanconi anemia, complementation group D2 |
| FOXM1 | forkhead box M1 |
| GTSE1 | G-2 and S-phase expressed 1 |
| KIF11 | kinesin family member 11 |
| KIF20A | kinesin family member 20A |
| KIF23 | kinesin family member 23 |
| KIF2C | kinesin family member 2C |
| KIF4A | kinesin family member 4A |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MCM10 | MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) |
| MCM2 | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) |
| MCM5 | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) |
| MKI67 | antigen identified by monoclonal antibody Ki-67 |
| NEK2 | NIMA (never in mitosis gene a)-related kinase 2 |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| PLK1 | polo-like kinase 1 (Drosophila) |
| PRC1 | protein regulator of cytokinesis 1 |
| PRIM1 | primase, polypeptide 1, 49 kDa |
| PTTG1 | pituitary tumor-transforming 1 |
| RAD51AP1 | RAD51 associated protein 1 |
| RAD54L | RAD54-like (S. cerevisiae) |
| RRM2 | ribonucleotide reductase M2 polypeptide |
| STMN1 | stathmin 1/oncoprotein 18 |
| TCF19 | transcription factor 19 (SC1) |
| TK1 | thymidine kinase 1, soluble |
| TOP2A | topoisomerase (DNA) II alpha 170 kDa |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TTK | TTK protein kinase |
| TYMS | thymidylate synthetase |