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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2019 Mar 27;62(7):3753–3772. doi: 10.1021/acs.jmedchem.9b00351

Scheme 1.

Synthesis of Compounds for Exploring the RHS Heterocyclic Moietya

Scheme 1

aReagents and conditions: (a) Cs2CO3, DMSO, 125 °C, 48 h; (b) Pd(dppf)Cl2, KOAc, B2(pin)2, dioxane, 80 °C, 18 h; (c) Pd(PPh3)4, K2CO3, dioxane, H2O2, 120 °C, 25 min.