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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2019 Mar 27;62(7):3753–3772. doi: 10.1021/acs.jmedchem.9b00351

Table 3.

SFSR of the Linking Heteroatom Moiety of Compound 1a

graphic file with name nihms-1022494-t0029.jpg
Cmpd Linking Heteroatom EC50(nM) pEC50 ± SEM Emax ± SEM(%) EC50(nM) pEC50 ± SEM Emax ± SEM(%) Bias for cAMP accumulation
1 graphic file with name nihms-1022494-t0030.jpg 0.25 9.61 ± 0.18 61 ± 3 114 6.94 ± 0.16 48 ± 3 7.7
20 graphic file with name nihms-1022494-t0031.jpg 16 7.81 ± 0.04 98 ± 1 >10,000 <5.00 N.D. N.C.
21 graphic file with name nihms-1022494-t0032.jpg 88 7.05 ± 0.03 79 ± 1 N.A. N.A. N.A. N.C.
22 graphic file with name nihms-1022494-t0033.jpg 36 7.45 ± 0.05 80 ± 1 N.A. N.A. N.A. N.C.
23 graphic file with name nihms-1022494-t0034.jpg 100 6.98 ± 0.09 67 ± 3 N.A. N.A. N.A. N.C.
24 graphic file with name nihms-1022494-t0035.jpg 320 6.50 ± 0.03 78 ± 1 N.A. N.A. N.A. N.C.
25 graphic file with name nihms-1022494-t0036.jpg 1,100 5.94 ± 0.07 68 ± 3 >10,000 <5.00 N.D. N.C.
a

EC50 and EMAX values are the mean of at least three independent experiments performed in triplicate with standard error of the mean (SEM) values. N.A. no activity at maximum concentration tested (10−4 M), N.D. not determined, N.C. not calculable.