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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2019 Mar 27;62(7):3753–3772. doi: 10.1021/acs.jmedchem.9b00351

Table 5.

SFSR of the Middle Phenyl Ring Moiety of Compound 5a

graphic file with name nihms-1022494-t0050.jpg
Cmpd Middle Phenyl Ring EC50(nM) pEC50 ± SEM Emax ± SEM(%) EC50(nM) pEC50 ± SEM Emax ± SEM(%) Bias for cAMP accumulation
5 graphic file with name nihms-1022494-t0051.jpg 2.7 8.57 ± 0.03 95 ± 1 180 6.75 ± 0.09 63 ± 3 1.3
37 graphic file with name nihms-1022494-t0052.jpg 530 6.27 ± 0.09 29 ± 1 N.A. N.A. N.A. N.C.
38 graphic file with name nihms-1022494-t0053.jpg 110 6.96 ± 0.13 30 ± 1 N.A. N.A. N.A. N.C.
39 graphic file with name nihms-1022494-t0054.jpg N.A. N.A. N.A. N.A. N.A. N.A. N.C.
40 graphic file with name nihms-1022494-t0055.jpg 10 8.00 ± 0.05 91 ± 1 790 6.10 ± 0.11 54 + 3 1.7
41 graphic file with name nihms-1022494-t0056.jpg 2.3 8.64 ± 0.03 94 ± 1 270 6.57 ± 0.12 93 ± 5 1.5
42 graphic file with name nihms-1022494-t0057.jpg N.A. N.A. N.A. N.A. N.A. N.A. N.C.
43 graphic file with name nihms-1022494-t0058.jpg 190 6.71 ± 0.04 57 ± 1 >10,000 <5.00 N.D. N.C.
a

EC50 and EMAX values are the mean of at least three independent experiments performed in triplicate with standard error of the mean (SEM) values. N.A. no activity at maximum concentration tested (10−4 M), N.D. not determined, N.C. not calculable.