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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2019 Mar 27;62(7):3753–3772. doi: 10.1021/acs.jmedchem.9b00351

Table 6.

SFSR of the LHS Moiety of Compound 41a

graphic file with name nihms-1022494-t0059.jpg
Cmpd LHS EC50(nM) pEC50 ± SEM Emax ± SEM(%) EC50(nM) pEC50 ± SEM Emax ± SEM(%) Bias for cAMP accumulation
41 graphic file with name nihms-1022494-t0060.jpg 2.3 8.64 ± 0.03 94 ± 1 270 6.57 ± 0.12 93 ± 5 1.5
44 graphic file with name nihms-1022494-t0061.jpg 770 6.11 ± 0.02 83 ± 1 N.A. N.A. N.A. N.C.
45 graphic file with name nihms-1022494-t0062.jpg 67 7.18 ± 0.07 61 ± 2 N.A. N.A. N.A. N.C.
46 graphic file with name nihms-1022494-t0063.jpg 2.2 8.661 0.06 93 ± 2 >10,000 <5.00 N.D. N.C.
47 graphic file with name nihms-1022494-t0064.jpg 7.8 8.11 ± 0.07 78 ± 2 N.A. N.A. N.A. N.C.
48 graphic file with name nihms-1022494-t0065.jpg 180 6.74 ± 0.06 54 ± 1 N.A. N.A. N.A. N.C.
49 graphic file with name nihms-1022494-t0066.jpg 270 6.57 ± 0.05 65 ± 1 N.A. N.A. N.A. N.C.
50 graphic file with name nihms-1022494-t0067.jpg N.A. N.A. N.A. >10,000 <5.00 N.D. N.C.
a

EC50 and EMAX values are the mean of at least three independent experiments performed in triplicate with standard error of the mean (SEM) values. N.A. no activity at maximum concentration tested (10−4 M), N.D. not determined, N.C. not calculable.