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Atomic force microscopy shows that rough LPS forms larger aggregates than smooth LPS. Saline solutions containing 20 μmol/L of smooth (A) or rough LPS (B) were analyzed with an atomic force microscope (see “Experimental Procedures” for additional experimental details). (A) is a representative view of small-sized aggregates of smooth LPS. (B) is a representative view of large-sized aggregates of rough LPS.
