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. 2019 Jul 30;10:1686. doi: 10.3389/fimmu.2019.01686

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Copyright © 2019 Imgenberg-Kreuz, Almlöf, Leonard, Sjöwall, Syvänen, Rönnblom, Sandling and Nordmark.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential DNA methylation uniquely associated to SLE or to pSS. (A) Box plots showing DNA methylation levels at unique DMCs in SLE compared to controls at FADD and HIF3A. (B) Functional pathway analysis of SLE-specific differential methylation. The bar plot depicts the results of the functional pathway analysis of the unique genes (n = 401) that were uniquely associated with SLE in the SLE case-ctrl EWAS. Significantly enriched pathways are presented on the y-axis with their corresponding –log₁₀(p) on the x-axis. (C) Box plots showing DNA methylation levels at unique DMCs in pSS compared to controls at LDLRAP1, HLA-DPA1, cg12899747 (intergenic, chr 3), cg08468401 (intergenic, chr 3), and cg22805491 (intergenic, chr 14).