TABLE 2.
List of chaperones and proteasome-related proteins and their function associated to protein homeostasis and pluripotency control in different PSCs models.
| Proteins and families | Function in PSCs biology | References | |
| Chaperome | HSP90 | Pluripotency maintenance and mesoderm differentiation of mESCs | Bradley et al., 2012 |
| STAT3 translocation to nucleus and NANOG negative regulation in mESC | Setati et al., 2010 | ||
| Endoderm differentiation of iPSCs | Jing et al., 2017 | ||
| HOP | STAT3 expression and phosphorylation and NANOG expression in mESCs | Longshaw et al., 2009 | |
| Murine embryonic survival | Beraldo et al., 2013 | ||
| HSP70 | Surface marker of pluripotency in hESCs | Alekseenko et al., 2012 | |
| Differentiation of mESCs | Baharvand et al., 2008; Battersby et al., 2007; Saretzki et al., 2007 | ||
| Differentiation and survival of iPSCs | Brodarac et al., 2015 | ||
| Early differentiation of hESCs and mESCs | Park et al., 2011 | ||
| HSP60 | OCT4 expression, proliferation, self-renewal and survival of mESCs | Seo et al., 2018 | |
| HSP40 | mESCs differentiation into smooth muscle cells Endoderm differentiation marker | Wong et al., 2014; Wang and Gudas, 1988 | |
| HSP27 | NANOG inactivation and neuronal differentiation of human placenta-derived cells | Cheng et al., 2016 | |
| Proteasome related | PSMD14 | OCT4 regulation in mESCs and iPSCs | Buckley et al., 2012 |
| FBXW7 | Negative regulation of c-MYC protein stability in mESCs and iPSCs | ||
| NRF2 | Pluripotency maintenance in hESCs and iPSCs | Jang et al., 2014 | |
| PSMD11 | Functional proteasome complexes formation in hESC and iPSC | Vilchez et al., 2012 | |
| F0X04 | PSMD11 expression regulator in hESCs and iPSC | ||
| L1TD1 | Downregulation leads to decrease in SOX2 and PSMD11 of hESC | Emani et al., 2015 | |
| C0PS2 | NANOG protein stability regulator of mESCs | Zhang et al., 2016 | |
| WWP2 | Promotes OCT4 and SOX2 proteasome degradation in mESCs | Xu et al., 2004, 2009, Fang et al., 2014 | |
| SET7 | SOX2 methylation and proteasome degradation promotion in mESCs Transcriptional activity inhibition in mESCs | Fang et al., 2014 | |
| AKT1 | SOX2 phosphorylation and proteasome degradation prevention in mESCs | ||
| UBR5 | Proteostasis machinery regulator in hESCs and iPSCs | Koyuncu et al., 2018 | |
| FBXW8 | Polyubiquitynates NANOG and mESCs | Kim et al., 2014 | |
| USP21 | NANOG protein stabilization in mESCs and hESCs | Jin et al., 2016; Liu et al., 2017 | |
| USP26 | NANOG and SOX2 genes inhibition in hESCs | Ning et al., 2017 | |