Figure 3.

Experimental approach to evaluate p-Tvax and OX40 agonists anti-cancer properties. Two s.c. vaccinations were administered with p-Tvax separated by 1 week. Two days before each p-Tvax immunization, CpG adjuvant injections were performed. To engage the OX40 receptor on T cells, we performed two injections of the OX86 mAb, with the first dose injected 5 d prior to the last p-Tvax vaccination, and the second on the same day as the last p-Tvax injection. Untreated controls and mice treated with the different immunotherapies were followed for tumor dimension and survival.