Figure 1.

Skin concentrations (μmol drug/g skin) after application of (a) 0.5% w/v propranolol in PBS solution or (b) 0.5% w/v timolol ophthalmic solution to full thickness excised porcine skin under various dosing regimens (single dose, once a day dosing, or twice a day dosing) for various study lengths; n=3 for each condition. Bars represent mean ± SD. *: p<0.05; **: p<0.01; ***: p<0.001