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Skin concentrations (n=3) of propranolol and timolol for intact skin (black bars) and skin pretreated with (a) 250 μm solid MNs or (b) 500 μm solid MNs (white bars). Timolol skin concentrations were significantly increased after insertion with the 250 μm length MNs; no significant differences in skin concentrations were observed for timolol after insertion with the 500 μm length MNs or for propranolol after insertion with either MN length. Bars represent mean ± SD. *: p<0.05
