Table 1.

Intact skin concentrations (μmol drug/g skin) of propranolol and timolol under various dosing regimens (n=3)

Study	Drug application	Study length	Skin concentrations (μmol drug/g skin)
			Propranolol	Timolol
Single dose study	At the beginning of the study	24 hours	4.82 ± 1.45	1.91 ± 0.35
		36 hours	3.45 ± 0.77	1.56 ± 0.29
		48 hours	3.22 ± 0.85	1.77 ± 0.16
		72 hours	2.53 ± 0.87	1.41 ± 0.08
Once a day study	Every 24 hours	24 hours	4.82 ± 1.45	1.91 ± 0.35
		48 hours	9.17 ± 3.27	4.00 ± 0.95
		72 hours	14.41 ± 1.28	3.33 ± 0.49
Twice a day study	Every 12 hours	24 hours	5.66 ± 0.61	1.57 ± 0.80
		36 hours	10.92 ± 0.71	1.63 ± 0.60
		48 hours	14.54 ± 2.36	1.27 ± 0.09