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. Author manuscript; available in PMC: 2019 Aug 9.
Published in final edited form as: J Org Chem. 2016 Apr 12;81(9):3924–3928. doi: 10.1021/acs.joc.6b00338

Table 1.

Optimization Studies: Tandem Process of 2a→4a

graphic file with name nihms-1044829-t0002.jpg
entry solvent base temp (°C) yielda (%)
1 acetone NaH 0 NRb
2 THF NaH 0 NRb
3 acetone K2CO3 80 <10
4 DMF K2CO3 80 54
a

Yield reported is the overall yield of 4a from 2a.

b

NR denotes no reaction occurred