(A) The CaMKII family tree within the human kinome (based on (Manning et al., 2002)). Also indicated are the different CaMK subfamilies as well as the classification of some CaM-regulated kinases that are not part of the CaMK family.
(B) Examples of CaMK domain organization: CaMKII, CaMKI, DAPK1, DAPK3, and Trio in schematic representation. DAPK3 and Trio are examples of CaMKs without CaM binding regulatory domain; DAPK1 and Trio are examples of CaMKs with complex domain structure. CaMKII contains a unique association domain that mediates 12meric holoenzyme assemblies (see Figure 3).