Skip to main content
. Author manuscript; available in PMC: 2020 Aug 7.
Published in final edited form as: Neuron. 2019 Aug 7;103(3):380–394. doi: 10.1016/j.neuron.2019.05.033

Figure 1. The CaMK family.

Figure 1.

(A) The CaMKII family tree within the human kinome (based on (Manning et al., 2002)). Also indicated are the different CaMK subfamilies as well as the classification of some CaM-regulated kinases that are not part of the CaMK family.

(B) Examples of CaMK domain organization: CaMKII, CaMKI, DAPK1, DAPK3, and Trio in schematic representation. DAPK3 and Trio are examples of CaMKs without CaM binding regulatory domain; DAPK1 and Trio are examples of CaMKs with complex domain structure. CaMKII contains a unique association domain that mediates 12meric holoenzyme assemblies (see Figure 3).