Table 1.
Clinicopathological characteristics of 325 patients with rectal cancer
| Clinicopathological feature | Total (n = 325) | Differentiation level of rectal cancer |
P-value | ||
|---|---|---|---|---|---|
| Poor differentiation (n = 26) | Moderate differentiation (n = 182) | Well differentiated (n = 117) | |||
| Age, mean ± SD (years) | 46.0 ± 10.2 | 54.6 ± 10.8 | 55.9 ± 11.1 | <0.001 | |
| Sex, n (%) | 0.430 | ||||
| Male | 241 (74.2) | 18 (69.2) | 140 (77.8) | 83 (70.9) | |
| Female | 84 (25.8) | 8 (30.8) | 42 (22.2) | 34 (29.1) | |
| T category before NCRT, n (%) | 0.622 | ||||
| T2 | 21 (6.5) | 2 (7.7) | 10 (5.5) | 9 (7.7) | |
| T3 | 234 (72.0) | 16 (61.5) | 133 (73.1) | 85 (72.6) | |
| T4 | 70 (21.5) | 8 (30.8) | 39 (21.4) | 23 (19.7) | |
| N category before NCRT, n (%) | 0.638 | ||||
| N0 | 71 (21.8) | 5 (19.2) | 44 (24.2) | 22 (18.8) | |
| N1 | 126 (38.8) | 9 (34.6) | 66 (36.3) | 51 (43.6) | |
| N2 | 128 (39.4) | 12 (46.2) | 72 (39.5) | 44 (37.6) | |
| Interval between NCRT and surgery, mean ± SD (days)a | 48.5 ± 26.4 | 53.6 ± 45.3 | 58.5 ± 45.0 | 0.494 | |
| Tumor location, n (%) | 0.409 | ||||
| Upper rectum | 32 (9.9) | 1 (3.9) | 21 (11.5) | 10 (8.5) | |
| Middle rectum | 82 (25.2) | 5 (19.2) | 51 (28.0) | 26 (22.2) | |
| Low rectum | 211 (64.9) | 20 (76.9) | 110 (60.5) | 81 (69.3) | |
| Surgical procedure, n (%) | 0.196 | ||||
| Open | 56 (17.2) | 8 (30.8) | 31 (17.0) | 17 (14.5) | |
| Hand-assisted | 12 (3.7) | 0 | 5 (2.7) | 7 (6.0) | |
| Laparoscopic | 257 (79.1) | 18 (69.2) | 146 (80.3) | 93 (79.5) | |
| Distance to the anal verge, mean ± SD (cm) | 3.9 ± 2.2 | 4.8 ± 2.6 | 5.0 ± 2.7 | 0.209 | |
| CRM status, n (%) | 0.062 | ||||
| Positive | 2 (0.6) | 1 (4) | 0 | 1 (0.9) | |
| Negative | 315 (99.4) | 24 (96) | 179 (100) | 112 (99.1) | |
| Number of lymph nodes dissected, mean ± SD | 8.8 ± 4.1 | 9.7 ± 5.4 | 9.5 ± 5.1 | 0.700 | |
| Pathological T category | 0.803 | ||||
| T0–T2 | 141 (43.4) | 11 (42.3) | 80 (44.0) | 50 (42.7) | |
| T3 | 171 (52.6) | 13 (50) | 96 (52.7) | 62 (53.0) | |
| T4 | 13 (4.0) | 2 (7.7) | 6 (3.3) | 5 (4.3) | |
| Pathological N category | <0.001 | ||||
| N0 | 278 (85.5) | 19 (73.1) | 155 (85.2) | 104 (88.9) | |
| N1 | 32 (9.9) | 0 (0) | 22 (12.1) | 10 (8.5) | |
| N2 | 15 (4.6) | 7 (26.9) | 5 (3.7) | 3 (2.6) | |
| TRGa | 0.147 | ||||
| 0 | 82 (26.1) | 12 (46.2) | 44 (24.2) | 26 (22.2) | |
| 1 | 99 (31.4) | 7 (26.9) | 52 (28.6) | 40 (34.2) | |
| 2–3 | 134 (42.5) | 7 (26.9) | 80 (44.0) | 47 (40.2) | |
| Down-staging of T category | 0.871 | ||||
| Yes | 149 (45.8) | 14 (53.8) | 80 (44.0) | 55 (47.0) | |
| No | 176 (54.2) | 12 (46.2) | 102 (56.0) | 62 (53.0) | |
| Down-staging of N category | 0.053 | ||||
| Yes | 225 (69.2) | 14 (53.8) | 122 (67.0) | 89 (76.1) | |
| No | 100 (30.8) | 12 (46.2) | 60 (33.0) | 28 (23.9) | |
| Response | 0.119 | ||||
| Yes | 263 (81.9) | 17 (65.4) | 149 (81.9) | 97 (82.9) | |
| No | 62 (19.1) | 9 (34.6) | 33 (18.1) | 20 (17.1) | |
| pCR | 0.276 | ||||
| Yes | 62 (19.1) | 8 (30.8) | 32 (17.6) | 22 (18.8) | |
| No | 263 (80.9) | 18 (69.2) | 150 (82.4) | 95 (81.2) | |
SD, standard deviation; NCRT, neoadjuvant chemoradiation; CRM, circumferential resection margin; TRG, tumor regression grade; pCR, pathological complete regression.
a
The data of 10 patients were missed and only 315 patients have complete information here.