Criteria	Yes	No	Other*	Notes
1. Research question or objective clearly stated	□	□	Choose an item.	Click here to enter text.
2. Study Population clearly defined	□	□	Choose an item.	Click here to enter text.
3. Participation rate of eligible persons at least 50%	□	□	Choose an item.	Click here to enter text.
4. All subjects selected from the same or similar populations (including the same time period)	□	□	Choose an item.	Click here to enter text.
5. Inclusion and exclusion criteria for being in the study pre-specified and applied uniformly to all participants	□	□	Choose an item.	Click here to enter text.
6. Exposures of interest were measured prior to the outcome being measured	□	□	Choose an item.	Click here to enter text.
7. For exposures that can vary in amount or level, the study examined different levels of the exposure as related to the outcome (e.g., categories of exposure, or exposure measured as continuous variable)	□	□	Choose an item.	Click here to enter text.
8. Exposure measures (independent variables) were clearly defined, valid, reliable, and implemented consistently across all study participants	□	□	Choose an item.	Click here to enter text.
9. Outcome measures (dependent variables) were clearly defined, valid, reliable, and implemented consistently across all study participants	□	□	Choose an item.	Click here to enter text.
10. Loss to follow-up after baseline was 20% or less	□	□	Choose an item.	Click here to enter text.
11. Key potential confounding variables were measured and adjusted statistically for their impact on the relationship between exposure(s) and outcome(s)	□	□	Choose an item.	Click here to enter text.

^*CD, cannot determine; NA, not applicable; NR, not reported