Table 5. Multivariate analysis for the progression of cerebral small vessel disease.

	Presence of cerebral SVD progressiona	Burden of cerebral SVD progressionb
Sex	1.32 (0.63–2.73)	1.08 (0.54–2.15)
Age	1.03 (0.99–1.07)†	1.03 (0.99–1.06)†
Body mass index	0.94 (0.84–1.06)	0.96 (0.84–1.06)
Hypertension	1.92 (0.93–3.99)†	1.84 (0.91–3.78)†
Klotho	0.75 (0.59–0.96)*	0.72 (0.56–0.92)*
FGF-23	1.07 (0.99–1.14)†	1.05 (1.00–1.10)*
Total cholesterol	0.99 (0.98–1.01)	0.99 (0.98–1.01)
Low-density lipoprotein	0.99 (0.97–1.00)	0.99 (0.98–1.01)
White blood cell count	1.06 (0.93–1.21)	1.04 (0.92–1.17)
Total calcium	1.85 (0.78–4.39)	1.46 (0.66–3.22)

Data are shown as odds ratio (95% confidence interval)

*: p<0.05,

^†: p<0.1. FGF-23: fibroblast growth factor-23.

^a: presence of~: any increase in total SVD score.

^b: burden of ~: increased point in total SVD score.