Table 2. Predictions of brain myelin by slow wave activity topography in children.
Associations between Frontal/Occipital ratio (F/O-ratio) of slow wave activity and brain myelin content as myelin water fraction (MWF) were calculated with Spearman and partial correlations controlling for ‘age at T1 or T2’ (n=13 for T1, n=14 for T2). To reduce the chance of falsepositive findings, we additionally performed false discovery rate (FDR) analysis. Significant associations (p<0.05) are presented in bold. With exclusion of the one subject with the T2 assessment only, results were overall consistent (n=13). Relationships with F/O-ratio at T2: Whole brain: Spearman correlation Rho= −0.29, p=0.33, pFDR=0.38; partial correlation: Rho= −0.74, p=0.006, pFDR=0.04. Superior longitudinal fasciculus: Spearman correlation Rho= −0.46, p=0.12, pFDR=0.17; partial correlation: Rho= −0.72, p=0.008, pFDR=0.04. Corpus callosum: Spearman correlation Rho= −0.35, p=0.24, pFDR=0.29; partial correlation: Rho= −0.49, p=0.11, pFDR=0.17. Optic radiation: Spearman correlation Rho= −0.18, p=0.57, pFDR=0.57; partial correlation: Rho= −0.37, p=0.23, pFDR=0.29.
| Myelin (MWF) at T2 | Whole brain | Superior longitudinal fasciculus |
Corpus callosum | Optic radiation | |||||
|---|---|---|---|---|---|---|---|---|---|
| Spearman correlation |
Partial correlation |
Spearman correlation |
Partial correlation |
Spearman correlation |
Partial correlation |
Spearman correlation |
Partial correlation |
||
| Slow wave activity topography | F/O-ratio at T1 |
Rho=0.84 p=0.0005 pFDR=0.009 |
Rho=0.70 p=0.01 pFDR=0.06 |
Rho=0.62 p=0.03 pFDR=0.09 |
Rho=0.50 p=0.10 pFDR=0.17 |
Rho=0.56 p=0.05 pFDR=0.13 |
Rho=0.51 p=0.09 pFDR=0.17 |
Rho=0.53 p=0.07 pFDR=0.15 |
Rho=0.29 p=0.36 pFDR=0.45 |
| F/O-ratio at T2 | Rho=−0.13 p=0.65 pFDR=0.69 |
Rho=−0.69 p=0.009 pFDR=0.06 |
Rho=−0.26 p=0.37 pFDR=0.45 |
Rho=−0.64 p=0.02 pFDR=0.07 |
Rho=−0.18 p=0.53 pFDR=0.61 |
Rho=−0.40 p=0.18 pFDR=0.28 |
Rho=−0.05 p=0.86 pFDR=0.86 |
Rho=−0.33 p=0.27 pFDR=0.39 |
|