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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2019 Mar 18;11(5):e1448. doi: 10.1002/wsbm.1448

Table 4.

Pharmacological tools that target Ca2+ release and Ca2+ influx channels.

Ion channel Activators Inhibitors
IP3R ci-IP3/PM(Caged IP3) (W. M. Zhang, Lin, & Sham, 2004) Heparin (Ehrlich, Kaftan, Bezprozvannaya, & Bezprozvanny, 1994), Xestospongin C (Gafni et al., 1997), 2-APB (Maruyama, Kanaji, Nakade, Kanno, & Mikoshiba, 1997)
RyR NAADP tetrasodium salt (Dammermann et al., 2009), Suramin (Hill, Kingston, & Sitsapesan, 2004) Dantrolene (Zhao, Li, Chen, Louis, & Fruen, 2001), JTV 519, Fumarate (Neumann, Diaz-Sylvester, Fleischer, & Copello, 2011), Ryanodine (C. P. Bianchi, 1997), Flecainide (Mehra, Imtiaz, van Helden, Knollmann, & Laver, 2014)
L-type Ca2+ channels (±)-Bay K 8644 (D. A. Greenberg, Cooper, & Carpenter, 1984), FPL 64176 (McDonough, Mori, & Bean, 2005) Amlodipine (Burges et al., 1987), (R)-(+)-Bay K 8644 (Mason, Gonye, Chester, & Herbette, 1989), Diltiazem (Kraus, Hering, Grabner, Ostler, & Striessnig, 1998), Isradipine (Hof, Scholtysik, Loutzenhiser, Vuorela, & Neumann, 1984), Verapamil (Lacinova, Ludwig, Bosse, Flockerzi, & Hofmann, 1995), Nifedipine (Stork & Cocks, 1994), Nimodipine (Izquierdo, 1990), Isradipine (Wada, Satoh, & Taira, 1985), Lercanidipine (S. Sonkusare, Srinivasan, Kaul, & Ramarao, 2005), Felodipine (Ljung, 1990)
T-type Ca2+ channels None known Mibefradil (Mehrke, Zong, Flockerzi, & Hofmann, 1994), ML 218 hydrochloride (Devergnas et al., 2016), Z 944 (Casillas-Espinosa et al., 2015), NNC 55–0369 (L. Huang et al., 2004), (2R/S)-6-PNG (Sekiguchi et al., 2018)
TRPM4 U73122 (Leitner et al., 2016) 9-Phenanthrol (Simard, Salle, Rouet, & Guinamard, 2012)
TRPC1 None known GsMTx4 (C. L. Bowman, P. A. Gottlieb, T. M. Suchyna, Y. K. Murphy, & F. Sachs, 2007)
TRPC3 GSK 1702934A (de la Cruz et al., 2017) Pyr3 (Kiyonaka et al., 2009)
TRPC4 None known ML 204 (Miller et al., 2011)
TRPC6 GSK 1702934A (de la Cruz et al., 2017), Flufenamic acid (Guinamard, Simard, & Del Negro, 2013) SAR 7334 (Maier et al., 2015), GsMTx4 (Charles L. Bowman, Philip A. Gottlieb, Thomas M. Suchyna, Yolanda K. Murphy, & Frederick Sachs, 2007)
TRPV1 Anandamide (Guinamard et al., 2013), (E)Capsaicin (Holzer, 2008), MRS 1477 (Kaszas et al., 2012), NADA (S. M. Huang et al., 2002), 6’ Iodoresiniferatoxin (Appendino et al., 2003), Arvanil (Szallasi & Di Marzo, 2000),
OLDA (Chu et al., 2003), Rinvanil (Nam et al., 2015)
A 425619 (El Kouhen et al., 2005), A 784168 (B. R. Bianchi et al., 2007), SB 366791 (Gunthorpe et al., 2004), SB 452533 (B. R. Bianchi et al., 2007), AMG 21629 (Tamayo et al., 2008), AMG 517 (Gavva et al., 2007), AMG 9810 (Doherty et al., 2005), BCTC (Pomonis et al., 2003), Capsazepine (Dickenson & Dray, 1991), 5’-Iodoresiniferatoxin (Wahl, Foged, Tullin, & Thomsen, 2001),
JNJ 17203212 (Swanson et al., 2005), L-R4W2 (Himmel, Kiss, Borvendeg, Gillen, & Illes, 2002)
α-Spinasterol (Trevisan et al., 2012)
TRPV3 Incensole Acetate(Moussaieff et al., 2008),
Farnesyl Pyrophosphate(Bang, Yoo, Yang, Cho, & Hwang, 2010),
Carvacrol, Eugenol, Thymol (H. Xu et al., 2006)
17R-resolvin D1 (Bang, Yoo, Yang, Cho, & Hwang, 2012),
Ruthenium Red (Amann & Maggi, 1991)
TRPV4 GSK1016790A (Willette et al., 2008), RN 1747 (Vincent et al., 2009) RN 9893 (Wei et al., 2015), GSK 2193874 (Hong et al., 2018), HC 067047 (Everaerts et al., 2010), RN 1734 (Vincent et al., 2009),
Ruthenium Red (Amann & Maggi, 1991)
TRPA1 ASP 7663 (Vincent et al., 2009), JT010 (Takaya et al., 2015), Resveratrol (Vancauwenberghe et al., 2017), Allyl Isothiocyanate (Iwasaki, Tanabe, Kobata, & Watanabe, 2008),
Optovin (Kokel et al., 2013)
A 967079 (J. Chen et al., 2011), AM 0902 (Schenkel et al., 2016), HC 030031 (Eid et al., 2008), AP 18 (Petrus et al., 2007), TCS 5861528 (Petrus et al., 2007)