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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2019 Mar 11;144(2):574–583.e5. doi: 10.1016/j.jaci.2019.03.002

Figure 1. EBV viremia EBV driven lymphoproliferation and impaired IFN-γ secretion in the patients.

Figure 1.

A. Circulating EBV viral load in P1. B. Immunohistochemistry of cervical LN from P1 showing a cluster of CD20+ B cells (left) and positive EBV (EBER) in situ hybridization (right) C. IFN-γ and IL-2 levels in supernatants of PHA Stimulated PBMCs from P1 and controls (n=3) in two independent experiments. D. Circulating EBV viral load P2. E. H&E stain of cervical LN from P2 showing a diffuse growth pattern (upper left), and immunohistochemistry showing negative CD20 staining (upper right), positive CD38 staining (lower left) and positive EBV (EBER) in situ hybridization (lower right) consistent with a DLBCL of plasmablastic subtype. F. IFN-γ and IL-2 levels in supernatants of PHA Stimulated PBMCs from P2 and controls (n=3) in two independent experiments. Results represent the mean, columns and bars represent mean + SEM. *** p<0.001, ns= not significant.