Table 1:

TFCE results for the association of BMIz with gray and white matter volume and density

Volume
Gray Matter
BMIz+
Area	k	X	Y	Z	TFCE p	Sig h2/TFCE	AEpD21/TFCE	AEpD21/Sig h2
Brainstem	1399	−4	−35	−13	0.019	0.77	0.77	1.00
L Thalamus	1152	−16	−28	2	0.037	1.00	1.00	1.00
R Thalamus	1919	9	−31	−3	0.029	0.71	0.71	1.00
BMIz−
Area	k	X	Y	Z	TFCE p	Sig h2/TFCE	AEpD21/TFCE	AEpD21/Sig h2
L Uncus/medial OFC	5897	−17	6	−32	0.001	0.30	0.30	1.00
R Uncus/medial OFC	5727	19	8	−35	0.001	0.17	0.17	1.00
Density
Gray Matter
BMIz−
Area	k	X	Y	Z	TFCE p	Sig h2/TFCE	AEpD21/TFCE	AEpD21/Sig h2
L Cerebellum	6448	−32	−58	−51	0.025	0.10	0.09	0.99
R Cerebellum	8392	32	−55	−51	0.024	0.20	0.20	1.00
R Uncus/OFC/inferior temporal/fusiform/ amygdala/hippocampus/parahippocampal/ inferior, middle and superior frontal/insula/ B cingulate/medial frontal/frontal pole	127507	15	48	−22	0.012	0.12	0.08	0.73
L Uncus/OFC/inferior temporal/insula/ supramarginal/pallidum/amygdala/ hippocampus	29978	−27	9	−35	0.023	0.20	0.16	0.82
R Inferior occipital	127	46	−80	2	0.046	0.00	0.00	-
White Matter
BMIz−
Area	k	X	Y	Z	TFCE p	Sig h2/TFCE	AEpD21/TFCE	AEpD21/Sig h2
Brainstem	1976	−2	−30	−15	0.019	0.55	0.22	0.40

Table 1: Regions significantly associated with BMIz. TFCE = Threshold Free Cluster Enhancement analyses. BMIz+/− = Structures positively/negatively associated with BMIz. k = Volume, XYZ = MNI peak coordinate, TFCE p = peak TFCE significance, Sig h2/TFCE = proportion of TFCE cluster voxels significantly heritable, AEpD21/TFCE = proportion of TFCE cluster voxels with significant shared genetics, AEpD21/Sig h2 = proportion of significantly heritable voxels with significant shared genetics. L = Left, R = Right, B = Bilateral. / = cluster covers multiple regions. OFC = Orbitofrontal cortex.