Skip to main content
. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Andrology. 2019 May 1;7(5):631–643. doi: 10.1111/andr.12632

Figure 5). Model showing BC-CC crosstalk via the ANGII signaling pathway.

Figure 5)

Axiopodia in BCs cross the TJs and are in contact with the lumen. Luminal ANGII stimulates AGTR2 in BCs and induces the production of NO, which then diffuses out to reach CCs, where it produces cGMP via activation of soluble guanylate cyclase (sGC). cGMP triggers V-ATPase apical accumulation and increases proton secretion by CCs. ANGII is produced by testicular ACE (t-ACE), which is attached to the sperm membrane via a GPI linker.