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. 2019 Jun 20;37(9):2004–2018. doi: 10.1002/jor.24337

Figure 2.

Figure 2

Reflexive grip strength and forepaw mechanical sensitivity. (A) and (B) Reflexive grip strength in food‐restricted control (FRC) and HRHF task groups. HRHF rats were tested at a naïve timepoint immediately prior to the 5‐week shaping period, immediately post‐shaping (task week 0) and after performing the HRHF task for 3 weeks, with subsets receiving treatments in the final 2 weeks. FRC rats were tested at similar times. (C) Forepaw mechanical sensitivity assayed in task week 3 using nylon monofilaments with milliNewton (mN) sizes shown. a: p < 0.05, compared with matched FRC group; b: p < 0.05, compared with untreated HRHF rats; c: p < 0.05, compared with HRHF + hIgG rats; n.s., not significant. Number of limbs tested per group: HRHF, n = 12; HRHF + FG‐3019, n = 10–12; HRHF + hIgG, n = 10; FRC, n = 10–25; FRC + Saline, n = 10; FRC + hIgG, n = 10, and FRC + FG‐3019, n = 10, bilateral results included for latter two groups [Color figure can be viewed at wileyonlinelibrary.com]