. 2019 Jun 20;37(9):2004–2018. doi: 10.1002/jor.24337

Table 3.

Inflammatory Responses in Flexor Digitorum Muscle, Median Nerve, and Serum

Analyte and Tissue	FRC/FRC + Saline (n = 5–16)	3‐Week HRHF Untreated (n = 6–12)	3‐Week HRHF + FG‐3019 (n = 4–9)
Muscle CD68‐immunopositive cells, no. of cells/mm² (n = 7–11/group)	0.20 ± 0.08	0.62 ± 0.06^aa	0.33 ± 0.03^bb
	0.20 ± 0.08	0.62 ± 0.06^aa	0.33 ± 0.03^bb
Nerve CD68‐immunopositive cells, no. of cells/mm² (n = 9–16/group)	6.01 ± 0.88	20.91 ± 2.92^aa	11.02 ± 2.65 ^b
	6.01 ± 0.88	20.91 ± 2.92^aa	11.02 ± 2.65 ^b
Serum CCL2/MCP‐1, pg/ml (n = 4–6/group)	92.85 ± 58.06	494.0 ± 52.91^aa	156.2 ± 68.39^bb
Serum CCL3/MIP1a, pg/ml (n = 4–6/group)	13.6 ± 2.43	8.07 ± 2.03	9.12 ± 1.01
Serum CXCL2/MIP2, pg/ml (n = 4–6/group)	10.62 ± 2.77	9.25 ± 3.89	10.74 ± 3.24
Serum CXCL5/LIX, pg/ml (n = 4–6/group)	778.5 ± 93.42	1069.0 ± 127.40	874.4 ± 60.20
Serum CXCL10/IP‐10, pg/ml (n = 4–6/group)	172.4 ± 33.24	345.8 ± 65.80 ^a	120.5 ± 12.05 ^b
Serum IL‐10, pg/ml (n = 4–6/group)	0.00 ± 0.00	112.30 ± 45.41 ^a	1.48 ± 1.47 ^b
Serum IL‐18, pg/ml (n = 4–6/group)	20.76 ± 6.16	20.16 ± 5.22	12.82 ± 7.08

FRC, food‐restricted control; HRHF, high repetition high force; IgG, immunoglobulin G.

Significant changes are bolded.

^{^a}

p < 0.05 and ^aa p < 0.01, compared with matched FRC group.

^{^b}

p < 0.05 and p < 0.01, compared with untreated HRHF rats.