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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Apr 15;4(8):715–725. doi: 10.1016/j.bpsc.2019.03.014

Figure 4. Frontoinsular response to task predicts future depressive symptom severity.

Figure 4.

One multiple regression analysis tested the associations between task-related functional connectivity in a priori frontoinsular networks and future depressive symptom severity (Center for Epidemiological Studies- Depression Subscale, CESD, at 15-day follow-up). In this regression, task-related (A) hypoconnectivity between insula and regions of frontoparietal network (FN) did not reach a significant association with future depression (p=0.15), but (B) hyperconnectivity between insula and regions of default network (DN), was associated with higher severity of future depression. Task-related connectivity (C) among regions within FN, or (D) among regions within-DN, was not associated with future depression. Note: On y-axis, CESD scores are normalized and residualized for demographic covariates (age and gender) and baseline depression severity (CESD); on x-axis, task-related network functional connectivity is normalized and residualized for covariates. Reported are standardized ß from regression analyses. A significant ß represents a significant independent variable in the regression, *p<0.05.