Table 1.
Summary of Sample Clinical Characteristics.
| Diagnostic States | HCC | Cirrhosis | ||||
|---|---|---|---|---|---|---|
| Number | 72 | 58 | ||||
| Age (year, mean ± SD) | 62.9 ± 9.4 | 58.0 ± 7.7 | ||||
| Gender (F/M) | 23/49 | 27/31 | ||||
| Etiology | NASH a (n = 17) | ALC a,b (n = 20) | HCV b (n = 35) | NASH a (n = 19) | ALC a,b (n = 19) | HCV b (n = 20) |
| ALTc | 38.4 ± 22.6 | 38.8 ± 28.6 | 89.1 ± 49.5 | 33.3 ± 14.7 | 36.6 ± 17.6 | 79.9 ± 48.4 |
| ASTc | 62.3 ± 35.6 | 60.8 ± 36.3 | 108.2 ± 50.6 | 45.7 ± 15.8 | 55.9 ± 44.2 | 104.3 ± 73.3 |
| Albumin (g/dL)c | 3.6 ± 0.6 | 3.3 ± 0.7 | 3.6 ± 0.6 | 3.7 ± 0.6 | 3.6 ± 0.6 | 3.3 ± 0.7 |
| TBili (mg/dL)c | 1.2 ± 1.0 | 2.4 ± 3.9 | 1.8 ± 3.3 | 1.2 ± 1.0 | 1.5 ± 1.1 | 1.6 ± 0.9 |
| INRc | 1.0 ± 0.13 | 1.2 ± 0.18 | 1.1 ± 0.21 | 1.2 ± 0.20 | 1.1 ± 0.15 | 1.2 ± 0.14 |
| MELDc | 8.4 ± 2.9 | 11.2 ± 4.6 | 9.3 ± 3.7 | 10.9 ± 5.0 | 9.0 ± 3.4 | 10.6 ± 2.6 |
| AFPc (ng/mL, median) | 7.2 | 5.9 | 33.0d | 3.4e | 2.6 | 4.1 |
| AFP < 20 ng/mL (%) | 70.6% | 80% | 44.1% | 94.4% | 100% | 90.0% |
| TNM stage (I/II/III/IV) | 8/3/3/3 | 6/5/6/3 | 6/12/7/10 | NA | NA | NA |
| Early HCC (%) | 64.7% | 55.0% | 51.4% | NA | NA | NA |
aSamples were provided by the UT Southwestern Medical Center, Dallas, TX.
bSamples were provided by the Division of Gastroenterology, University of Michigan, Ann Arbor, MI. NASH, nonalcoholic steatohepatitis; ALC, alcohol consumption; HCV, hepatitis C virus.
cALT, AST, Albumin, TBili, INR, MELD, and AFP values were provided by the Hospitals. ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBili, total bilirubin; INR, international normalized ratio; MELD, model for end-stage liver disease. Values are presented as mean ± SD or median.
dOne patient with HCC induced by HCV had AFP missing.
eOne patient with Cirrhosis induced by NASH had AFP missing.