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. 2019 Aug 9;5:128. doi: 10.1038/s41420-019-0206-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Overview of the RNA-seq data in TCGA of 17 cancer cohorts showing the highest OPTN expression in renal cell carcinoma followed by PDAC (expressed in terms of median FPKM). b Kaplan–Meier curves of high and low OPTN expression in PDAC versus the survival of patients (log rank p-value (1.4e-2). Both a and b data were retrieved from human protein atlas (https://www.proteinatlas.org/ENSG00000123240-OPTN/pathology/tissue/pancreatic+cancer). c Expression of autophagy related genes and receptors in the PDAC cell cohort with a sample size of 179 patients. The mean control expression is indicated by the straight line across all groups. All expression levels shown are >7.5 log2 rsem (Rna-Seq by Expectation Maximization)