Table 1.
Characteristics of the study population and comparison of several disease characteristics after stratification according to an absolute lymphocyte count < or ≥1.2 × 109/l
| Whole population (n = 1023) | ALC < 1.2 × 109/l (n = 502) | ALC ≥ 1.2 × 109/l (n = 521) | p Value | |
|---|---|---|---|---|
| WHO 2016, n (%) | ||||
| MDS-SLD | 75 (7.3) | 44 (8.8) | 31 (6.0) | |
| MDS-MLD | 311 (30.4) | 172 (34.3) | 139 (26.7) | |
| MDS-RS-SLD | 47 (4.6) | 16 (3.2) | 31 (6.0) | |
| MDS-RS-MLD | 93 (9.1) | 37 (7.4) | 56 (10.7) | |
| MDS(del5q) | 115 (11.2) | 42 (8.4) | 73 (14.0) | |
| MDS-EB-1 | 167 (16.3) | 70 (13.9) | 97 (18.6) | |
| MDS-EB-2 | 203 (19.8) | 114 (22.7) | 89 (17.1) | |
| MDS-U | 12 (1.2) | 7 (1.4) | 5 (1.0) | |
| IPSS-R, n (%) | ||||
| Very low | 58 (5.7) | 24 (4.8) | 34 (6.5) | |
| Low | 325 (31.8) | 148 (29.5) | 177 (34) | |
| Intermediate | 263 (25.7) | 126 (25.1) | 137 (26.3) | |
| High | 188 (18.4) | 92 (18.3) | 96 (18.4) | |
| Very high | 189 (18.5) | 112 (22.3) | 77 (14.8) | |
| IPSS-R cytogenetic risk group, n (%) | ||||
| Very good | 36 (3,5) | 19 (3.8) | 17 (3.3) | |
| Good | 624 (61) | 287 (57.2) | 337 (64.7) | |
| Intermediate | 171 (16.7) | 92 (18.3) | 79 (15.2) | |
| Poor | 74 (7.2) | 43 (8.6) | 31 (6) | |
| Very poor | 118 (11.5) | 61 (12.2) | 57 (10.9) | |
| Age median [years] (range) | 66 (15–91) | 67 (17–91) | 65 (15–86) | 0.076 |
| Gender, n (%) | ||||
| Male | 598 (58.5) | 310 (61.8) | 288 (55.3) | 0.036 |
| Leukemic transformation, n (%) | 254 (24.8) | 119 (23.7) | 135 (25.9) | |
| Deaths, n (%) | 645 (63) | 319 (63,5) | 326 (62.6) | |
| Lost to follow-up, n (%) | 35 (3.4) | 22 (4.4) | 13 (2.5) | |
| Hemoglobin, median [g/l] (range) | 95 (3–16.9) | 93 (3.7–16.9) | 97 (3–16.6) | 0.04 |
| Neutrophil count, median [×109/l] (range) | 1.62 (0–10.59) | 1.35 (0.26–10.59) | 1.92 (0–10.24) | <0.001 |
| Platelet count, median [×109/l] (range) | 116 (2–1540) | 100 (3–987) | 138 (2–1540) | <0.001 |
| LDH | ||||
| Data available, n (%) | 869 (84.9) | 438 (87.3) | 431 (82.7) | |
| LDH, median [U/l] (range) | 200 (49–1848) | 207 (76–900) | 197 (49–1848) | 0.049 |
| LDH > ULN [240 U/l], n (%) | 274 (31.5) | 152 (34.7) | 122 (28.3) | 0.056 |
| Blasts bone marrow, median [%] (range) | 3 (0–19) | 3 (0–19) | 3 (0–19) | 0.577 |
| Blasts peripheral blood, median [%] (range) | 0 (0–19) | 0 (0–19) | 0 (0–19) | 0.235 |
| Bone marrow fibrosis data available, n (%) | 558 (54.5) | 262 (52.2) | 296 (56.8) | |
| With bone marrow fibrosis, n (%) | 79 (14.2) | 31 (11.8) | 48 (16.2) | 0.146 |
| Transfusion-dependency | ||||
| Data available, n (%) | 425 (41.5) | 205 (40.8) | 220 (42.2) | |
| Transfusion dependent, n (%) | 223 (52.5) | 119 (58) | 104 (47) | 0.032 |