Table 3.

Factors affecting prognosis in MDS patients without hematopoietic stem cell transplantation or induction chemotherapy (n = 721) in univariate analysis and two multivariate models (multivariate I: absolute lymphocyte count < 1.2 × 10⁹/l together with the cytogenetic risk groups according to IPSS-R; multivariate II: absolute lymphocyte count < 1.2 × 10⁹/l together with the cytogenetic risk groups according to IPSS-R, bone marrow blast count and the degree of cytopenias)

	Univariate				Multivariate I				Multivariate II
	p	Hazard ratio	95% confidence interval		p	Hazard ratio	95% confidence interval		p	Hazard ratio	95% confidence interval
Age ≥ 65	<0.001	2.32	1.87	2.86
Male gender	0.005	1.15	1.04	1.26
Hb < 10 g/dl	<0.001	1.47	1.21	1.78					<0.001	1.56	1.29	1.89
Neutrophil count < 1.8 × 109/l	0.001	1.39	1.15	1.67					0.959	1.0	0.82	1.23
Platelet count < 100 × 109/l	<0.001	1.88	1.56	2.27					<0.001	1.56	1.28	1.89
Bone marrow blasts > 5%	<0.001	2.60	2.13	3.18					<0.001	2.25	1.82	2.79
IPSS-R cytogenetic risk category	<0.001	1.55	1.41	1.69	<0.001	1.52	1.39	1.67	<0.001	1.38	1.26	1.51
IPSS-R category	<0.001	1.68	1.55	1.82
Transfusion dependency	0.001	1.73	1.27	2.36
LDH > ULN (240 U/l)	<0.001	1.91	1.53	2.38
Absolute lymphocyte count < 1.2 × 109/l	0.001	1.35	1.13	1.63	0.022	1.24	1.03	1.49	0.086	0.85	0.70	1.02