Table 5.
Additional prognostic value of different factors for patients within the IPSS-R low-risk group without hematopoietic stem cell transplantation or induction chemotherapy (n = 265)
| Unvariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
| p Value | Hazard ratio | 95% CI | p Value | Hazard ratio | 95% CI | |||
| Age > 65 | <0.001 | 3.31 | 2.25 | 4.88 | <0.001 | 3.21 | 2.15 | 4.80 |
| LDH > ULN (240 U/l) | <0.001 | 2.31 | 1.51 | 3.53 | <0.001 | 2.58 | 1.67 | 3.98 |
| Absolute lymphocyte count <1.2 × 109/l | 0.002 | 1.68 | 1.21 | 2.34 | 0.033 | 1.46 | 1.03 | 2.08 |
| Male gender | 0.054 | 1.39 | 0.99 | 1.93 | ||||
| Transfusion dependency | 0.075 | 1.61 | 0.95 | 2.71 | ||||
| Bone marrow fibrosis | 0.691 | 0.87 | 0.45 | 1.69 | ||||
| Hb < 10 g/dl | 0.287 | 1.20 | 0.86 | 1.66 | ||||
| Neutrophil count < 1.8 × 109/l | 0.148 | 0.79 | 0.57 | 1.09 | ||||
| Platelet count < 100 × 109/l | 0.174 | 0.73 | 0.47 | 1.15 | ||||
| Bone marrow blasts > 5% | 0.916 | 1.04 | 0.49 | 2.23 | ||||
| IPSS-R cytogenetic risk category | 0.213 | 1.44 | 0.81 | 2.57 | ||||