Fig. 4.

SASPs and Inflammatory cytokines upregulated with CS ameliorated in p16^−/− lungs. a Cytokines associated with senescent-associated secretory phenotype (SASP) and b inflammation on p16^+/+ and p16^−/− lungs exposed to RA or CS. IL-6 *p = 0.0499, **p = 0.0043 vs. p16^+/+ CS, CXCL-1 *p = 0.0084, IL-13 *p = 0.05, **p = 0.0260, CCL-2 *p = 0.0006 vs. p16^+/+ RA **p = 0.0009 vs. p16^+/+ CS, RANTES *p = 0.0346, **p = 0.0267 vs. p16^+/+ CS, Eotaxin *p = 0.0221 vs. p16^+/+ RA, **p = 0.0010 vs. p16^+/+ CS, IP-10 *p = 0.0372 vs. p16^+/+ RA, **p = 0.0108, IL-5 *p = 0.0308, **p = 0.0377, IL-9 *p = 0.0425, IL-17a *p = 0.0234, **p = 0.05 vs. p16^+/+ CS. N = 4–12 lungs per group