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. 2019 Aug 9;9(8):62. doi: 10.1038/s41408-019-0226-4

Fig. 3. Partial karyotypes of three patients showing concomitant 17p deletions originating from a jumping translocation of 1q12 to 17p.

Fig. 3

FISH probes for 1q12 (red) and 1q21 (green) are shown on the left. SKY image-classified colors for chromosome 1 (yellow), chromosome 3 (gray), chromosome 9 (white), chromosome 17 (blue), and chromosome 18 (fuchsia), and chromosome 22 (pink). FISH probes for TP53 (green) and ERBB2 (red). a Patient no 30 showing chromosomes in brackets from left to right, normal chromosomes 1 with FISH (left) and SKY (right). Middle brackets show two different der(3) RCs both with 1q12 and 1q21. In the brackets on right the chromosomes 17 show hybridization of the normal chromosome 17 with probes TP53 (green) and ERBB2 (red) in their normal positions. The der(1;17) shows the deletion of TP53 (no green signal) and ERBB2 (red) in normal position. In the right bracket the der(1;17) is shown with the 1q replacing 17p and normal positions of 1q12 (red) and 1q21 (green) on 1q. The SKY on the right shows 1q (yellow) replacing 17p and the 17q (blue). b Patient no 42 with brackets on far left showing 1q FISH with one normal chromosome 1 (left) and a small der(1) on (right) with large deletions of both 1p and 1q. Bracket middle left shows a der(9) with 1q12 and 1q21 (arrows) on the distal 9q. Brackets middle right shows the normal 17 showing TP53 (green) and ERBB2 (red), the der(1;17) showing loss of TP53 (green) and presence of ERBB2 (red). The bracket on right shows the same der(1;17) chromosome hybridized with 1q12 (red) and 1q21(green) and SKY (right) showing 1q (yellow) replacing the short arm of 17 (blue). Far right bracket shows 1q FISH (left) with 1q12 and 1q21 on 22, and SKY of der(22) with 1q (yellow) translocated to 22 (pink). A total of five copies of 1q21, three of which are distributed to RCs 9q, 17p, and 22q. c Patient no 49 in brackets on the left are normal chromosomes 1 by FISH and SKY. Middle brackets show normal TP53 (green) and ERBB2 (red) left and der(17) with deleted 17p (green) by FISH. The brackets on right show normal 1q12 and 1q21 by FISH and 1q replacing 17p (blue) by 1q (yellow) by SKY. Bracket on far right shows an inverted duplication of 1q21 on chromosome 18 with copies of 1q21 on both sides of 1q12 (left) by FISH. SKY showing 1q (yellow) on distal end of 18 (fuchsia)