Skip to main content
. 2019 Aug 9;9(8):62. doi: 10.1038/s41408-019-0226-4

Fig. 5. A partial karyotype of patient no 14 showing multiple JT1q12s resulting in dispersed insertions of the MET region (7q31).

Fig. 5

This clone shows a total of six copies of 1q12 and 1q21, and four copies of MET are present in this cell, normal chromosomes 1, 6, and 7 not shown. a Metaphase FISH shows two copies each for 1q12 (red) and 1q21(green) on the der(7q) (left), rehybridization with FISH probes for 7q21 (red) and MET (7q31, green) (middle) indicates the normal locations for these loci, and SKY classification colors (right) shows 1q (yellow) on distal 7q (salmon). b FISH probes for 1q12 (red) and 1q21 (green) shows one copy of both probes translocated on 6q (left), when rehybridized with MET (7q31, green), the 6q shows MET is inserted resulting in a der(6) with extra copies of 1q12, 1q21, and MET (middle). The SKY on right shows 6 (magenta), 7q MET regions (salmon) in middle, and 1q (yellow) distal. c Fish probes for 1q12 and 1q21 (left) shows an apparent direct duplication on 1q; the same chromosome 1 rehybridized with MET (middle) shows an insertion of MET into the 1q12 pericentromeric region of chromosome 1. On right SKY colors show insertion of 7q (salmon) material into chromosome 1q (yellow)