Table 3.
Top Gene Ontology-Defined BPs in Six Transcriptomic Modules Correlated With Lung Function Traits
| Module | P Value | |
|---|---|---|
| Dark green, adaptive immunity | Graft-vs-host disease (keg) | < .001 |
| Natural killer cell mediated cytotoxicity (keg) | < .001 | |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (rea) | < .001 | |
| Natural killer cell mediated immunity (BP) | .013 | |
| Antigen processing and presentation (keg) | .029 | |
| Cellular defense response (BP) | .043 | |
| Dark gray, cell cycle | Mitotic cell cycle process (BP) | < .001 |
| Cell Cycle (rea) | < .001 | |
| DNA metabolic process (BP) | < .001 | |
| Cell cycle (keg) | < .001 | |
| Histone kinase activity (MF) | < .001 | |
| RHO GTPases Activate Formins (rea) | < .001 | |
| Protein localization to chromosome, centromeric region (BP) | < .001 | |
| G1/S-Specific Transcription (rea) | < .001 | |
| Chromosome condensation (BP) | .014 | |
| Proteasome-mediated ubiquitin-dependent protein catabolic process (BP) | .017 | |
| Oocyte meiosis (keg) | .018 | |
| Signal transduction by p53 class mediator (BP) | .026 | |
| SUMOylation of DNA replication proteins (rea) | .027 | |
| G0 and Early G1 (rea) | .037 | |
| Dark olive green, asthma microRNAs | MI:hsa-miR-423-5p (mi) | < .001 |
| MI:hsa-miR-615-5p (mi) | < .001 | |
| MI:hsa-miR-564 (mi) | .025 | |
| MI:hsa-miR-339-5p (mi) | .028 | |
| MI:hsa-miR-214 (mi) | .034 | |
| MI:hsa-miR-331-3p (mi) | .036 | |
| Poly(A) RNA binding (MF) | .043 | |
| MI:hsa-miR-874 (mi) | .046 | |
| Pink, translational | RNA binding (MF) | < .001 |
| RNA processing (BP) | < .001 | |
| Ribonucleoprotein complex biogenesis (BP) | < .001 | |
| Translation (BP) | < .001 | |
| Mitochondrion organization (BP) | .022 | |
| Structural constituent of ribosome (MF) | .044 | |
| Negative regulation of translational initiation in response to stress (BP) | .046 | |
| DNA metabolic process (BP) | .05 | |
| Plum, innate immunity | Innate immune system (rea) | < .001 |
| Antimicrobial humoral response (BP) | < .001 | |
| Heparin binding (MF) | < .001 | |
| Serine-type endopeptidase activity (MF) | < .001 | |
| Extracellular matrix organization (rea) | .011 | |
| Yellow, transcriptional | RNA binding (MF) | < .001 |
| mRNA metabolic process (BP) | < .001 | |
| Cotranslational protein targeting to membrane (BP) | < .001 | |
| Structural constituent of ribosome (MF) | < .001 | |
| Protein transporter activity (MF) | < .001 | |
| Macromolecular complex subunit organization (BP) | < .001 | |
| Mitochondrion organization (BP) | < .001 | |
| Posttranscriptional regulation of gene expression (BP) | < .001 | |
| Multi-organism metabolic process (BP) | .027 | |
| Ribonucleoprotein complex localization (BP) | .033 | |
| Viral transcription (BP) | .04 | |
BP = biologic process; keg = KEGG-defined biologic pathway; MF = molecular function; mi = regulatory motif in miRBase microRNA; rea = reactome-defined biologic pathway.