. 2018 Jun 13;154(2):335–348. doi: 10.1016/j.chest.2018.05.038

Table 4.

Association Between Metabolite Modules and Lung Function Traits After Adjustment for Confounders

Metabolite Module	Trait	β (95% CI)	P Value
Red	Baseline FEV₁/FVC ratio	−0.001 (−0.0018 to −0.0002)	.019^a
	Post-BD FEV₁/FVC ratio	−0.0014 (−0.0023 to −0.0004)	.004^a
Purple	Baseline FEV₁/FVC ratio	0.0009 (0.0001 to 0.0017)	.028^a
Medium purple, lipid	Baseline FEV₁	−0.1386 (−0.2808 to 0.0036)	.057
Dark red	Baseline FEV₁/FVC ratio	0.0009 (0.0001 to 0.0017)	.029^a
	FEV₁ BD response	−0.0007 (−0.0014 to 1.75 × 10⁻⁵)	.057
Light cyan	Baseline FEV₁/FVC ratio	−0.0008 (−0.0016 to 3.45 × 10⁻⁵)	.062
	FEV₁ BD response	0.0007 (1.65 × 10⁻⁵ to 0.0014)	.046^a
Tan, purine	PD20	−0.0065 (−0.0103 to −0.0027)	.001^a
	Baseline FEV₁/FVC ratio	0.0009 (0.0001 to 0.0017)	.028^a
	Post-BD FEV₁/FVC ratio	0.0017 (0.0007 to 0.0026)	.001^a

Adjusted for age, weight, height, sex, and treatment regimen. Only three of the significant modules (red, medium purple, and tan) could be assigned functional names. See Table 1 and 2 legends for expansion of abbreviations

Significant at the 95% significance level.