Table 5.

Enriched Biologic Pathways and Processes in Six Metabolomic Modules Correlated With Lung Function Traits

Module	Trait Association	No. of Metabolite Features	No. of Hub Features	Enriched Pathways Among Known Metabolites
Red, ubiquinone	Baseline FEV1/FVC ratioa; post-BD FEV1/FVC ratioa	449	412	No enriched pathways: known metabolites— Ubiquinone-2; C18:0 Mono Acyl Glycerol; (S)-2-Propylpiperidine; Polyoxyethylene (600) monoricinoleate
Medium purple, lipid	Baseline FEV1	537	518	GPI-anchor biosynthesis (P = .034); sphingolipid metabolism (P = .061); glycerolipid metabolism (P = .077); glycerophopholipid metabolism (P = .093)
Tan, purine	PD20; baseline FEV1/FVC ratio; post-BD FEV1/FVC ratio	147	141	Caffeine metabolism (P = .017); purine metabolism (P = .075)
Dark red	Baseline FEV1/FVC ratioa; baseline FEV1	93	85	No enriched pathways; no known metabolites
Light cyan	Baseline FEV1/FVC ratio; baseline FEV1a	111	98	No enriched pathways: known metabolites—methyl dihydrojasmonate
Purple	Baseline FEV1/FVC ratioa	411	330	No enriched pathways: known metabolites—tetradecyl sulfate

GPI = glycosylphosphatidylinositol. See Table 1 and 2 legends for expansion of other abbreviations.

^aTrait retained significance in multivariate regression model.