Table 6.
Results of the Integrated Pathway Enrichment Analysis Based on the Genes and Metabolites of Correlated Lung Function-Associated Transcriptomic and Metabolomics Modules
| Gene Module | Metabolite Module | Pathway Name | No. of Overlapping Genes | No. of Overlapping Metabolites | Joint P Value |
|---|---|---|---|---|---|
| Dark olive green, asthma microRNAs | Medium purple, lipid | Immune System | 409 | 4 | 9.38 × 10−11,a |
| Membrane Trafficking | 152 | 1 | 1.46 × 10−8,a | ||
| B cell receptor signaling pathway - Homo sapiens (human) | 31 | 1 | 5.12 × 10−8,a | ||
| Adipocytokine signaling pathway - Homo sapiens (human) | 23 | 2 | 6.64 × 10−7,a | ||
| Signalling by NGF | 106 | 2 | 1.03 × 10−6,a | ||
| Adaptive Immune System | 168 | 3 | 1.42 × 10−6,a | ||
| TNF alpha Signaling Pathway | 33 | 1 | 1.47 × 10−6,a | ||
| Neurotrophin signaling pathway - Homo sapiens (human) | 34 | 2 | 1.84 × 10−6,a | ||
| Insulin resistance - Homo sapiens (human) | 27 | 3 | 2.23 × 10−6,a | ||
| Innate Immune System | 276 | 2 | 3.88 × 10−6,a | ||
| Dark olive green, asthma microRNAs | Red, ubiquinone | TCA cycle | 12 | 1 | 4.53 × 10−4 |
| Citrate cycle | 12 | 1 | 7.98 × 10−4 | ||
| The citric acid (TCA) cycle and respiratory electron transport | 40 | 1 | 3.74 × 10−3 | ||
| Respiratory electron transport_ ATP synthesis by chemiosmotic coupling_ and heat production by uncoupling proteins | 27 | 1 | 7.12 × 10−3 | ||
| Sulfide oxidation to sulfate | 2 | 1 | 9.24 × 10−3 | ||
| Oxidative phosphorylation - Homo sapiens (human) | 27 | 1 | .010 | ||
| Respiratory electron transport | 20 | 1 | .012 | ||
| Electron Transport Chain | 19 | 1 | .013 | ||
| Degradation of cysteine and homocysteine | 2 | 1 | .035 | ||
| Pyrimidine metabolism | 6 | 1 | .043 | ||
| Pink, translational | Red, ubiquinone | Respiratory electron transport | 17 | 1 | 5.06 × 10−4,a |
| The citric acid (TCA) cycle and respiratory electron transport | 26 | 1 | 9.86 × 10−4 | ||
| Respiratory electron transport_ ATP synthesis by chemiosmotic coupling_ and heat production by uncoupling proteins | 18 | 1 | 2.06 × 10−3 | ||
| Citrate cycle | 7 | 1 | 2.91 × 10−3 | ||
| Oxidative phosphorylation - Homo sapiens (human) | 18 | 1 | 2.96 × 10−3 | ||
| Electron Transport Chain | 14 | 1 | 2.97 × 10−3 | ||
| TCA cycle | 6 | 1 | 5.96 × 10−3 | ||
| Arginine Proline metabolism | 8 | 1 | .020 | ||
| Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human) | 2 | 1 | .027 | ||
| Sulfur amino acid metabolism | 4 | 1 | .029 |
Top ten pathways/processes enriched for both genes and metabolites are shown. Dark red metabolite module contained no known metabolites and so could not be included in the analyses.
a
Retains significance when applying the Benjamini-Hochberg false discovery rate.