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. 2019 Aug 9;39(8):BSR20180441. doi: 10.1042/BSR20180441

Figure 1. MiR-382 enhanced CDDP-induced apoptosis in CRC cell lines.

Figure 1

(A) MiR-382 expression significantly decreased in specimens of CRC patients that had a poor chemoresponse (PR, n=38) compared with those with a good chemoresponse (GR, n=64). (B) Overexpression of miR-382 increased CDDP-induced apoptosis in HCT116 cells. (C) Inhibition of miR-382 inhibited CDDP-induced apoptosis in HCT116 cells. After 24 h of transfection, cells were treated with DMSO or 10 μM CDDP for 24 h, followed by a flow cytometric assay. (D) Overexpression of miR-382 increased CDDP-induced caspase 3 cleavage, whereas inhibition of miR-382 suppressed CDDP-induced caspase 3 cleavage in HCT116 cells. All of the data are presented as the mean ± SD from three independent experiments; *P<0.05 and **P<0.01.