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. 2019 Aug 9;39(8):BSR20180441. doi: 10.1042/BSR20180441

Figure 3. KLF12 and HIPK3 are targets of miR-382.

Figure 3

Expression of KLF12 and HIPK3 was negatively regulated by miR-382 at both protein levels (A) and mRNA (B). (C) Sequence alignment of miR-382 with the 3′-UTR of the KLF12 and HIPK3 genes. (D) KLF12 and HIPK3; HEK293T cells were cotransfected with an indicated pMIR-3′-UTR luciferase reporter construct and pre-miR-382 or respective controls (Ctrl. Oligo). Analysis by 3′-UTR luciferase reporter assay. (E) The inverse correlation between miR-382 and KLF12 or HIPK3 mRNA expression in CRC samples (n=10) by linear regression analysis; *P≤0.05 and **P<0.01.