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. 2019 Aug 9;39(8):BSR20180441. doi: 10.1042/BSR20180441

Figure 4. KLF12 and HIPK3 regulated chemoresistance and cell growth in CRC cells.

Figure 4

(A) Overexpression of HIPK3 protected cells from death induced by CDDP treatment. (B) Overexpression of KLF12, but not HIKP3, stimulated cell growth. (C) In the CRC Xenograft model, tumor growth was increased by KLF12 overexpression, but not by HIPK3 overexpression. (D) HIPK3 overexpression induced resistance to CDDP in the LS1034 CRC Xenograft model. (E) Overexpression of KLF12 stimulated tumor growth and HIPK3 overexpression induced resistance to CDDP in a miR-382-overexpressing LS1034 Xenograft model; *P≤0.05 and **P<0.01.